disease – USMAIL24.COM https://usmail24.com News Portal from USA Sat, 23 Mar 2024 01:59:57 +0000 en-US hourly 1 https://wordpress.org/?v=6.4.3 https://usmail24.com/wp-content/uploads/2024/01/Untitled-design-1-100x100.png disease – USMAIL24.COM https://usmail24.com 32 32 195427244 What we know about the disease Bray Wyatt had https://usmail24.com/bray-wyatt-illness/ https://usmail24.com/bray-wyatt-illness/#respond Sat, 23 Mar 2024 01:59:57 +0000 https://usmail24.com/bray-wyatt-illness/

WWE wrestler Bray Wyatt passed away in August 2023 at the age of just 36. It has since been reported that the star was suffering from an illness in the lead up to his death. 2 WWE wrestler Bray Wyatt passed away in August 2023 at the age of 36Credit: Monica Schipper/FilmMagic Who was Bray […]

The post What we know about the disease Bray Wyatt had appeared first on USMAIL24.COM.

]]>

WWE wrestler Bray Wyatt passed away in August 2023 at the age of just 36.

It has since been reported that the star was suffering from an illness in the lead up to his death.

2

WWE wrestler Bray Wyatt passed away in August 2023 at the age of 36Credit: Monica Schipper/FilmMagic

Who was Bray Wyatt?

Bray Wyatt, whose real name was Windham Rotunda, was an American professional wrestler.

He was born on May 23, 1987 in Florida and died on August 24, 2023.

The star was the son of wrestler Mike Rotunda and grandson of wrestler Blackjack Mulligan.

His brother, Taylor Rotunda, also performed in the WWE under the name Bo Dallas.

Wyatt was once married to real estate agent Samantha Rotunda.

The couple split in 2017, but welcomed two daughters, Cadyn and Kendyl Rotunda, during their relationship.

Wyatt was then in a relationship with his fiancée JoJo Offerman.

She is also a professional wrestler, best known for her role on the reality show Total Divas.

Wyatt and Offerman welcomed a son named Knash Sixx in May 2019.

Their daughter, Hyrie Von, was born the following year.

After Wyatt’s death, it was confirmed that all proceeds from his merchandise would go to his family.

A statement on the WWE website read: “In the wake of Bray Wyatt’s death, WWE will donate all net proceeds to JoJo Offerman and his children.”

What disease did Bray Wyatt have?

Wyatt had not been seen on TV since February 2023, and there were rumors that he was dealing with an injury.

It has since been reported that he was suffering from heart problems caused by a bout of Covid-19.

Wrestling reporter Sean Ross Sapp shared online that Wyatt had made progress shortly before his death.

He posted on Twitter: “I was cleared to reveal that Windham Rotunda (Bray Wyatt) got COVID earlier this year which aggravated his heart problems. There was a lot of positive progress towards his return and his recovery.

“Unfortunately today he had a heart attack and passed away.”

According to the Email onlinethe WWE had taken precautions to ensure that Wyatt could stabilize his long-term health before he died.

They report that his illness was “both career and life threatening.”

WWE wrestler Bray Wyatt watches from the sidelines during the XFL match between the DC Defenders and Tampa Bay Vipers on March 1, 2020 at Raymond James Stadium in Tampa, Florida

2

WWE wrestler Bray Wyatt watches from the sidelines during the XFL match between the DC Defenders and Tampa Bay Vipers on March 1, 2020 at Raymond James Stadium in Tampa, FloridaCredit: Mark LoMoglio/Icon Sportswire via Getty Images

What was Bray Wyatt’s cause of death?

Wyatt’s death was confirmed by WWE on August 25, 2023.

The promotion said in a statement: “WWE is saddened to learn that Windham Rotunda, also known as Bray Wyatt, passed away on Thursday, August 24 at the age of 36.”

It has since been reported that he died following a heart attack, but the official cause of death has yet to be confirmed by family or authorities.

The post What we know about the disease Bray Wyatt had appeared first on USMAIL24.COM.

]]>
https://usmail24.com/bray-wyatt-illness/feed/ 0 99806
Kate Middleton’s preventative chemotherapy explained: How cancer-fighting drugs with brutal side effects will try to prevent Princess of Wales’ disease from returning https://usmail24.com/kate-middleton-preventative-chemotharapy-explained-effects-princess-wales-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/kate-middleton-preventative-chemotharapy-explained-effects-princess-wales-htmlns_mchannelrssns_campaign1490ito1490/#respond Fri, 22 Mar 2024 22:39:21 +0000 https://usmail24.com/kate-middleton-preventative-chemotharapy-explained-effects-princess-wales-htmlns_mchannelrssns_campaign1490ito1490/

The Princess of Wales today revealed she is undergoing preventative chemotherapy following her shock cancer diagnosis. Chemotherapy uses powerful drugs to attack tumors and is typically given to directly treat cancer or shrink a tumor in preparation for surgery. As in the case of Kate Middleton, chemo can also be used as a preventive option […]

The post Kate Middleton’s preventative chemotherapy explained: How cancer-fighting drugs with brutal side effects will try to prevent Princess of Wales’ disease from returning appeared first on USMAIL24.COM.

]]>

The Princess of Wales today revealed she is undergoing preventative chemotherapy following her shock cancer diagnosis.

Chemotherapy uses powerful drugs to attack tumors and is typically given to directly treat cancer or shrink a tumor in preparation for surgery.

As in the case of Kate Middleton, chemo can also be used as a preventive option in the hope of preventing the return of cancer.

Today, Kate, 42, said in a statement that she has undergone this preventive form of chemotherapy. She started treatment at the end of February.

At the time, it was believed that the reason for Kate’s surgery was not cancer.

Today she said subsequent tests showed it was cancerous.

Kate was then advised to undergo preventive chemotherapy and described herself as being in the ‘early stages’ of that treatment.

Preventive chemotherapy, also called adjuvant chemotherapy, aims to prevent cancer from returning once the main tumor has been removed from the body.

Cancer can spread to other parts of the body, a process called metastasis, in which small cancer cells break off the main tumor and take root elsewhere.

These “new” cancers can be difficult to detect, so doctors who specialize in treating cancer, called oncologists, often advise patients to undergo preventive chemotherapy in an attempt to eliminate any remaining traces of the disease.

Preventive chemotherapy is usually administered as an infusion or tablets, where they are then carried throughout the body by the bloodstream.

Depending on the type, chemotherapy can be administered in a hospital or at the patient’s home.

There are more than 100 types of chemotherapy drugs, but they all work in a similar way and circulate through the blood.

The drugs are cytotoxic, meaning they are toxic to cells and especially to cells that are dividing rapidly.

Because cancer cells divide more than healthy cells, they are more affected by chemotherapy, which is why it is used as a treatment for the disease.

However, other types of fast-growing cells, such as hair, bone marrow, skin and the lining of the digestive system, are also damaged.

This leads to some of the famous side effects of chemotherapy, such as hair loss or thinning, fatigue, easier bruising and bleeding, an increased risk of infection, diarrhea or constipation, nausea or vomiting, rash, and more.

Often a patient undergoing chemotherapy is also taking other medications intended to alleviate or combat some of these symptoms.

The specific dosage and type of chemotherapy used varies depending on the type of cancer.

The Princess of Wales with her children in her Mother’s Day portrait, which has now taken on significance given her diagnosis

The Prince and Princess of Wales were spotted together last week as William attended The Commonwealth Day Service at Westminster Abbey

The Prince and Princess of Wales were spotted together last week as William attended The Commonwealth Day Service at Westminster Abbey

The Princess of Wales said her family (pictured together on December 25) 'need some time, space and privacy while I complete my treatment'

The Princess of Wales said her family (pictured together on December 25) ‘need some time, space and privacy while I complete my treatment’

Catherine, Princess of Wales, attends the opening of Evelina London's new pediatric surgery department on December 5

Catherine, Princess of Wales, attends the opening of Evelina London’s new pediatric surgery department on December 5

The effectiveness of preventive chemotherapy varies considerably from patient to patient.

Factors that influence its success include the specific type of cancer, when the cancer was originally treated, the patient’s age, and whether he or she has any other health problems.

The specific type of cancer Kate has has not been revealed.

Around 375,000 cases of cancer are diagnosed in the UK each year, with 167,000 patients dying from the disease each year.

Survival rates vary considerably by type of cancer. In total, 50 percent of cancer patients will still be alive ten years after their diagnosis.

Kate’s battle with cancer in her own words: Full emotional video statement from the Princess of Wales

I wanted to take this opportunity to personally thank you for all the wonderful messages of support and for your understanding while I was recovering from surgery.

It’s been an incredibly tough few months for our whole family, but I’ve had a fantastic medical team who have taken great care of me, for which I am so grateful.

In January I had major abdominal surgery in London and at the time my condition was deemed to be non-cancerous. The operation was successful. However, tests after the surgery revealed that cancer was present. My medical team therefore recommended that I undergo a course of preventative chemotherapy and I am now in the early stages of that treatment.

This obviously came as a huge shock, and William and I have done everything we can to process and manage this privately for the sake of our young family.

As you can imagine, this has taken time. It took me time to recover from major surgery before I could start my treatment. But the most important thing is that it took us time to explain everything

George, Charlotte and Louis in a way that suits them, and to reassure them that I will be fine.

As I told them; I am doing well and getting stronger every day by focusing on the things that will help me heal; in my mind, body and spirit.

Having William by my side is also a great source of comfort and reassurance. As does the love, support and kindness shown by so many of you. It means so much to both of us.

We hope you understand that we as a family now need some time, space and privacy while I complete my treatment. My work has always brought me a deep sense of joy and I look forward to being back when I am able, but for now I must focus on making a full recovery.

At this time I also think of all those whose lives have been touched by cancer. To anyone facing this disease in any form, please do not lose faith and hope. You are not alone.

The post Kate Middleton’s preventative chemotherapy explained: How cancer-fighting drugs with brutal side effects will try to prevent Princess of Wales’ disease from returning appeared first on USMAIL24.COM.

]]>
https://usmail24.com/kate-middleton-preventative-chemotharapy-explained-effects-princess-wales-htmlns_mchannelrssns_campaign1490ito1490/feed/ 0 99711
Kate Middleton reveals she has cancer: Princess of Wales, 42, bravely announces she is battling disease and undergoing ‘preventative chemotherapy’ – but reassures nation ‘I am going to be ok’ in highly emotional and unprecedented video message https://usmail24.com/kate-middleton-reveals-cancer-diagnosis-chemotherapy-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/kate-middleton-reveals-cancer-diagnosis-chemotherapy-htmlns_mchannelrssns_campaign1490ito1490/#respond Fri, 22 Mar 2024 18:11:30 +0000 https://usmail24.com/kate-middleton-reveals-cancer-diagnosis-chemotherapy-htmlns_mchannelrssns_campaign1490ito1490/

The Princess of Wales has announced tonight that she has been diagnosed with cancer aged 42 and is undergoing ‘preventative’ chemotherapy. In a deeply emotional video message, filmed at Windsor on Wednesday, Catherine revealed the news had come as a ‘huge shock’ and that she and William ‘have been doing everything we can to process and […]

The post Kate Middleton reveals she has cancer: Princess of Wales, 42, bravely announces she is battling disease and undergoing ‘preventative chemotherapy’ – but reassures nation ‘I am going to be ok’ in highly emotional and unprecedented video message appeared first on USMAIL24.COM.

]]>

The Princess of Wales has announced tonight that she has been diagnosed with cancer aged 42 and is undergoing ‘preventative’ chemotherapy.

In a deeply emotional video message, filmed at Windsor on Wednesday, Catherine revealed the news had come as a ‘huge shock’ and that she and William ‘have been doing everything we can to process and manage this privately for the sake of our young family’.

It came days after she was seen smiling with Prince William as they left their favourite farm shop close to their Windsor home. 

Speaking from a bench surrounded by daffodils and spring blossom, she said: ‘It has taken us time to explain everything to George, Charlotte and Louis in a way that is appropriate for them, and to reassure them that I am going to be ok.

‘As I have said to them; I am well and getting stronger every day by focusing on the things that will help me heal; in my mind, body and spirits. Having William by my side is a great source of comfort and reassurance too. As is the love, support and kindness that has been shown by so many of you. It means so much to us both.’

Catherine’s cancer was discovered only after she underwent major abdominal surgery at The London Clinic in January. Kensington Palace has said it will not be sharing details of what kind of cancer the princess has, or what stage of cancer it is and has asked people not to speculate.

It is understood that the King – who is also currently undergoing cancer treatment himself – and the Queen have both been informed of the news. 

Prime Minister Rishi Sunak has said the Princess of Wales has ‘the love and support of the whole country’ as her cancer battle was revealed this evening.

Sitting on a bench at Windsor, surrounded by spring flowers, the Princess of Wales has taken the extraordinary step of revealing to the world that she has cancer

At points the future queen was highly emotional as she spoke of her illness and her family

At points the future queen was highly emotional as she spoke of her illness and her family

Kate had a message for fellow cancer sufferers, telling them: 'You are not alone'

Kate had a message for fellow cancer sufferers, telling them: 'You are not alone'

Kate had a message for fellow cancer sufferers, telling them: ‘You are not alone’

The Princess of Wales with her children in her Mother's Day portrait, which now has added significance given her diagnosis

The Princess of Wales with her children in her Mother’s Day portrait, which now has added significance given her diagnosis

At the time of her abdominal surgery in January, Kensington Palace said that it was non-cancerous. They have confirmed again tonight that is the case and that no tests had confirmed the presence of cancer. However post-operative tests subsequently found that cancer ‘had been present’.

This evening’s announcement will send shockwaves around the world and came after weeks of speculation – and wild conspiracy theories – about her health. 

It also creates a fresh crisis for the British Royal Family at a time where King Charles is also battling cancer. In January Sarah, the Duchess of York, was diagnosed with skin cancer, just six months after being treated for breast cancer.

The princess is now on what has been described as a ‘recovery pathway’ having commenced a course of chemotherapy in late February.

It is for this reason that Prince William pulled out of a memorial service for his late godfather, King Constantine of Greece.

Kensington Palace has strongly asked people not to speculate on what cancer she has.

However they say that she is in ‘good spirits and focused on her recovery’.

‘She is hugely grateful to the medical team for the care they are providing to her,’ a spokesman said. ‘She now needs time, space and privacy to complete her treatment and make a full recovery.’

It is understood that the announcement was made tonight not because of unpleasant social media speculation about her health and whereabouts – although that has been upsetting – but because her children, Prince George, 10, Princess Charlotte, eight, and Prince Louis, five, broke up from school today, which gave them the opportunity to take them away privately and protect them from the inevitable public shock.

In her video statement the Princess, dressed casually in a stripped Breton top and jeans, said: ‘I wanted to take this opportunity to say thank you, personally, for all the wonderful messages of support and for your understanding whilst I have been recovering from surgery. It has been an incredibly tough couple of months for our entire family, but I’ve had a fantastic medical team who have taken great care of me, for which I am so grateful.

‘In January, I underwent major abdominal surgery in London and at the time, it was thought that my condition was non-cancerous. The surgery was successful. However, tests after the operation found cancer had been present. My medical team therefore advised that I should undergo a course of preventative chemotherapy and I am now in the early stages of that treatment.

‘This of course came as a huge shock, and William and I have been doing everything we can to process and manage this privately for the sake of our young family. As you can imagine, this has taken time. It has taken me time to recover from major surgery in order to start my treatment. But, most importantly, it has taken us time to explain everything to George, Charlotte and Louis in a way that is appropriate for them, and to reassure them that I am going to be ok.

‘As I have said to them; I am well and getting stronger every day by focusing on the things that will help me heal; in my mind, body and spirits. Having William by my side is a great source of comfort and reassurance too. As is the love, support and kindness that has been shown by so many of you. It means so much to us both.

‘We hope that you will understand that, as a family, we now need some time, space and privacy while I complete my treatment. My work has always brought me a deep sense of joy and I look forward to being back when I am able, but for now I must focus on making a full recovery.’

Even amidst her own personal anguish, there was a message for fellow cancer sufferers: ‘At this time, I am also thinking of all those whose lives have been affected by cancer. For everyone facing this disease, in whatever form, please do not lose faith or hope. You are not alone.’

The Prince and Princess of Wales were seen together last week as William went to the The Commonwealth Day Service at Westminster Abbey

The Prince and Princess of Wales were seen together last week as William went to the The Commonwealth Day Service at Westminster Abbey

The Princess of Wales said her family (pictured together on December 25) 'need some time, space and privacy while I complete my treatment'

The Princess of Wales said her family (pictured together on December 25) ‘need some time, space and privacy while I complete my treatment’

Kate’s cancer battle in her own words: The Princess of Wales’ emotional video statement in full 

I wanted to take this opportunity to say thank you, personally, for all the wonderful messages of support and for your understanding whilst I have been recovering from surgery.

It has been an incredibly tough couple of months for our entire family, but I’ve had a fantastic medical team who have taken great care of me, for which I am so grateful.

In January, I underwent major abdominal surgery in London and at the time, it was thought that my condition was non-cancerous. The surgery was successful. However, tests after the operation found cancer had been present. My medical team therefore advised that I should undergo a course of preventative chemotherapy and I am now in the early stages of that treatment.

This of course came as a huge shock, and William and I have been doing everything we can to process and manage this privately for the sake of our young family.

As you can imagine, this has taken time. It has taken me time to recover from major surgery in order to start my treatment. But, most importantly, it has taken us time to explain everything to

George, Charlotte and Louis in a way that is appropriate for them, and to reassure them that I am going to be ok.

As I have said to them; I am well and getting stronger every day by focusing on the things that will help me heal; in my mind, body and spirits.

Having William by my side is a great source of comfort and reassurance too. As is the love, support and kindness that has been shown by so many of you. It means so much to us both.

We hope that you will understand that, as a family, we now need some time, space and privacy while I complete my treatment. My work has always brought me a deep sense of joy and I look forward to being back when I am able, but for now I must focus on making a full recovery.

At this time, I am also thinking of all those whose lives have been affected by cancer. For everyone facing this disease, in whatever form, please do not lose faith or hope. You are not alone.

A source said this has been a ‘real shock’ for the couple and they have needed to take time to process the news personally and bring their young children to a place that they could ‘process this news about their mother’.

They have always wanted to shield them from the inevitable coverage her diagnosis will cause.

However she does have a very positive approach to her recovery and a positive mindset moving forwards.

A spokesman for the princess said: ‘We will not be sharing any further private medical information. The Princess has a right to medical privacy, as we all do.’

However her spokesman confirmed: ‘The Princess is now on a recovery pathway having commenced a course of preventative chemotherapy…in late February.’

The palace will not confirm how long her treatment is expected to last and has asked the media and public not to speculate.

It also said it would not confirm where her treatment would be taking place, a spokesman adding: ‘We will not be sharing any further private medical information. The Princess has a right to medical privacy, as we all do.’

Asked when the princess was given the news by her doctors, a spokesman explained: ‘Once post-operative tests had been completed and results reviewed.’

They added: ‘The Princess wanted to share this information when she and The Prince felt it was right for them as a family. ‘

A source said it had been ‘an incredibly tough couple of months for the entire family’ and it had been important for the princess to come to terms with her diagnosis, to recover form her surgery and begin her pathway to recovery.

Throughout this period the couple’s children have been her priority.

It is understood that William and Kate wanted to tell their children at a time that was right for them and to allow them to understand and process the news before it became public.

With the children having broken up from Lambrook School today for the Easter holidays this afternoon, they decided that now was the right time to share the statement.

Sources say their concern recently, despite global and social media speculation, was to put Catherine’s health and their children first.

It is now hoped, aides said, the speculation around the princess comes to a stop.

Kate at her "Together At Christmas" Carol Service at Westminster Abbey on December 8

Kate at her ‘Together At Christmas’ Carol Service at Westminster Abbey on December 8

Catherine, Princess of Wales attends the opening of Evelina London's new children's day surgery unit on December 5

Catherine, Princess of Wales attends the opening of Evelina London’s new children’s day surgery unit on December 5

The Princess of Wales arrives at the Shaping Us National Symposium at the Design Museum on November 15

The Princess of Wales arrives at the Shaping Us National Symposium at the Design Museum on November 15

Kate's cancer is for this reason that Prince William pulled out of a memorial service for his late godfather, King Constantine of Greece (pictured)

Kate’s cancer is for this reason that Prince William pulled out of a memorial service for his late godfather, King Constantine of Greece (pictured)

Catherine is apparently determined to go about her normal routine, which she sees as an important part of her recovery, and has asked for people to respect her privacy.

However it has been confirmed that the family will not be going to church at Windsor next Easter.

It is understood that Catherine wanted the time and space to come to terms with her diagnosis, to recover from her surgery and to then begin her pathway to recovery.

Throughout this period, her and William’s three young children have been their priority.

They wanted to be able to tell them at a time that was right for them and to allow them to understand and process the news before it became public, it is understood.

With the children now away from school on their Easter holidays, the couple feel now is the right time to share their update.

It has not been confirmed whether the princess is being treated on the NHS or privately.

However in selecting healthcare providers for The Princess, a balance of factors would have been considered by her medical team.

These include the most appropriate specialists for the condition, and the potential impact on other patients or on the resources of their healthcare providers and the privacy and security of the princess.

Kensington Palace have said they understand the worldwide interested the princess’s announcement would generate but have stressed that they will only provide an update when there is something significant to say in order to allow her to continue her treatment in private.

A spokesman said: ‘Their Royal Highnesses understand the interest this update will generate and are grateful for the public support they have received throughout this period. Kensington Palace will provide information, when the time is right, and The Princess is able to restart work and her duties. In the meantime, we would ask that the family’s privacy is respected. ‘

The Mail understands that Prince William will carry out engagements when the children return to school after the Easter holidays.

A spokesman said: ‘The Prince will continue to balance supporting his wife and family and maintaining his official duties as he has done since the start of the year. ‘

A source emphasised that this has been a difficult period for the Wales family. William has been focused on supporting his wife and children, while continuing to undertake engagements and work, and is extremely grateful for the support from the public.

The princess will remain out of the public eye for the time being.

Kensington Palace said: ‘The Princess will return to official duties when she is cleared to do so by her medical team. She is in good spirits and is focused on making a full recovery.’

It is understood she may be keen to attend events as and when she feels able to, in line with medical advice. Any initial public events will not necessarily signal a return to a regular public schedule.

A source added that she is in good spirits and focused on her recovery. She is hugely grateful to the medical team for the care they are providing to her and now needs to take the time and space to complete her treatment and make a full recovery.

The post Kate Middleton reveals she has cancer: Princess of Wales, 42, bravely announces she is battling disease and undergoing ‘preventative chemotherapy’ – but reassures nation ‘I am going to be ok’ in highly emotional and unprecedented video message appeared first on USMAIL24.COM.

]]>
https://usmail24.com/kate-middleton-reveals-cancer-diagnosis-chemotherapy-htmlns_mchannelrssns_campaign1490ito1490/feed/ 0 99551
Rapper BOSS dies at 54: singer who was signed by Russell Simmons in the 90s and passed the hit Deeper after kidney disease and stroke https://usmail24.com/rapper-boss-dead-54-singer-signed-russell-simmons-90s-hit-song-deeper-passes-renal-disease-stroke-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/rapper-boss-dead-54-singer-signed-russell-simmons-90s-hit-song-deeper-passes-renal-disease-stroke-htmlns_mchannelrssns_campaign1490ito1490/#respond Tue, 12 Mar 2024 16:28:39 +0000 https://usmail24.com/rapper-boss-dead-54-singer-signed-russell-simmons-90s-hit-song-deeper-passes-renal-disease-stroke-htmlns_mchannelrssns_campaign1490ito1490/

By Heidi Parker for Dailymail.com Published: 12:18 EDT, March 12, 2024 | Updated: 12:24 EDT, March 12, 2024 Rapper Bo$$, whose real name was Lichelle Marie Laws, has died at the age of 54. Rapper Bun B announced the news on social media on Monday evening. “Rest in peace to my big sister Lichelle Laws, […]

The post Rapper BOSS dies at 54: singer who was signed by Russell Simmons in the 90s and passed the hit Deeper after kidney disease and stroke appeared first on USMAIL24.COM.

]]>

Rapper Bo$$, whose real name was Lichelle Marie Laws, has died at the age of 54.

Rapper Bun B announced the news on social media on Monday evening. “Rest in peace to my big sister Lichelle Laws, aka Boss. One of the best female MCs and a dear friend,” he wrote, sharing a photo of the singer.

Her cause of death has not yet been announced.

It is believed she died due to complications from kidney disease, which she was first diagnosed with in 2011.

In 2017, a GoFundMe account was set up in her name after she suffered a stroke and a seizure.

She rose to fame for being the first female rapper signed to Def Jam by Russell Simmons.

Rapper Bo$$ – whose real name was Lichelle Marie Laws – has died at the age of 54. Seen in 1992 in New York

Rapper Bun B announced the news on social media on Monday evening.  “Rest in peace to my big sister Lichelle Laws, aka Boss.  One of the best female MCs and a dear friend,” he wrote, sharing a photo of the singer.  Seen in 1992

Rapper Bun B announced the news on social media on Monday evening. “Rest in peace to my big sister Lichelle Laws, aka Boss. One of the best female MCs and a dear friend,” he wrote, sharing a photo of the singer. Seen in 1992

In 1993 she released her first studio album, Born Gangstaz.

It turned out to be her only studio album during her career.

Her biggest hit was Deeper.

Jermaine Dupri, Jadakiss, 9th Wonder, Ed Lover and others paid tribute to the star on Instagram.

Bo$$ was born and raised in Detroit, but moved to Los Angeles after high school for her career.

One of DJ Quik’s team members discovered her during a performance.

She rose to fame for being the first female rapper signed to Def Jam by Russell Simmons.  Seen in LA in February

She rose to fame for being the first female rapper signed to Def Jam by Russell Simmons. Seen in LA in February

The post Rapper BOSS dies at 54: singer who was signed by Russell Simmons in the 90s and passed the hit Deeper after kidney disease and stroke appeared first on USMAIL24.COM.

]]>
https://usmail24.com/rapper-boss-dead-54-singer-signed-russell-simmons-90s-hit-song-deeper-passes-renal-disease-stroke-htmlns_mchannelrssns_campaign1490ito1490/feed/ 0 93030
Woman, 34, whose smear test was postponed during lockdown and was told not to worry when cancer diagnosis revealed her disease is now incurable https://usmail24.com/woman-34-smear-test-delayed-lockdown-told-not-worry-diagnosed-cancer-reveals-illness-incurable-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/woman-34-smear-test-delayed-lockdown-told-not-worry-diagnosed-cancer-reveals-illness-incurable-htmlns_mchannelrssns_campaign1490ito1490/#respond Tue, 12 Mar 2024 10:03:50 +0000 https://usmail24.com/woman-34-smear-test-delayed-lockdown-told-not-worry-diagnosed-cancer-reveals-illness-incurable-htmlns_mchannelrssns_campaign1490ito1490/

A young woman has revealed how she was diagnosed with incurable cancer after her smear test was postponed during lockdown. Abi Macnamara, 34, from Swansea, was told she was not a priority when her test was postponed in March 2020 due to Covid restrictions. In July, her test revealed she had stage one cervical cancer. […]

The post Woman, 34, whose smear test was postponed during lockdown and was told not to worry when cancer diagnosis revealed her disease is now incurable appeared first on USMAIL24.COM.

]]>

A young woman has revealed how she was diagnosed with incurable cancer after her smear test was postponed during lockdown.

Abi Macnamara, 34, from Swansea, was told she was not a priority when her test was postponed in March 2020 due to Covid restrictions.

In July, her test revealed she had stage one cervical cancer. She was told not to worry and was reassured that the disease had been caught early, making it ‘very treatable’.

But in December 2020, Abi was devastated when doctors told her the cancer had spread and was by then stage three.

The cancer has since returned twice and Abi has been told by doctors that the cancer is now incurable.

After being diagnosed with stage 1b cervical cancer, Abi Macnamara, 34, (pictured) underwent surgery to remove her cervix and cancerous lymph nodes

Abi, from Swansea, South Wales, is undergoing chemotherapy and immunotherapy but has been told her cancer is incurable

Abi, from Swansea, South Wales, is undergoing chemotherapy and immunotherapy but has been told her cancer is incurable

Abi pictured herself with her partner Nick in happier times.  Abi has always been active and competed in half marathons before she was diagnosed

Abi pictured herself with her partner Nick in happier times. Abi has always been active and competed in half marathons before she was diagnosed

Abi, who is undergoing palliative chemotherapy and immunotherapy, said: ‘I’m pretty sure I wouldn’t be where I am today if I’d had my smear test when it was supposed to be done.’

‘I’m struggling to accept where we are now and who is responsible for it. I don’t understand why cancer screening and treatment have been suspended.”

Abi received a letter asking her to book a smear test in 2020.

However, the test was postponed when Britain went into lockdown on March 26 and non-urgent care was postponed to free up staff and beds for the expected influx of seriously ill Covid-19 patients.

After Abi’s test in July revealed stage 1b cervical cancer, she underwent a radical trachelectomy in November – which was also postponed due to Covid – to remove her cervix and cancerous lymph nodes.

Abi said: ‘It came as a complete shock because I was really fit and healthy… I’d been running half marathons, I’d been keeping myself in shape.

‘I just put my complete trust in the hospital. I was told to keep calling every week for a date.’

While the surgeon told her the operation produced crisp margins – indicating all the cancer had been removed – Abi’s world was turned upside down over Christmas week when she discovered the cancer had spread.

Abi received more bad news when the cancer returned in January 2023, leading to acute kidney failure

Abi received more bad news when the cancer returned in January 2023, leading to acute kidney failure

Abi said her diagnosis came as a shock because she was fit and healthy

The treatment allowed her to continue to maintain a healthy lifestyle

Abi said her diagnosis came as a shock because she was fit and healthy

Abi underwent chemotherapy and radiation therapy, but received more bad news in January 2023 when the cancer returned, leading to acute kidney failure.

She was fitted with a urostomy bag for several months and received further rounds of chemotherapy and radiotherapy.

A scan at the end of August showed no signs of illness, but around Christmas she started feeling unwell again.

Abi was treated with antibiotics but she knew something was wrong, prompting her to bring forward her next scan.

The scan showed that the cancer had returned again, this time in her pelvic cavity.

Despite the delays in her treatment, Abi has received no apology from the hospital.

She said: ‘What irritates me is that everything was shut down because of Covid, but now everyone is living their normal lives and I have cancer. It shouldn’t have happened.

‘They never said sorry. The nurses were all fantastic, but the way the consultants spoke to you made you feel like they didn’t have time for you.

Abi refuses to hear her prognosis and is determined to stay as positive as possible for as long as possible

Abi refuses to hear her prognosis and is determined to stay as positive as possible for as long as possible

Her positive attitude is reinforced by her belief that some of life's greatest challenges can be the greatest teachers

Her positive attitude is reinforced by her belief that some of life’s greatest challenges can be the greatest teachers

“If they tell you too, that’s a huge thing for you.

‘I understand that they have to deal with this every day, but you are treated as if you are on a conveyor belt. There’s just a lack of humanity in all of this.

“I think there’s been a big wave of cancer patients and they can’t keep up with the demand.”

Abi refuses to be told her prognosis and although she has now resumed chemotherapy treatment, she hopes to explore other alternatives abroad.

She has continued to maintain a healthy lifestyle to give herself the best chance of responding well to treatment.

She said, ‘I don’t want it, I don’t want to become it. I want to be as positive as possible for as long as I can.

“I’m not burying my head in the sand, it’s a very serious situation I’m dealing with.

“But your greatest challenges in life can be your greatest teachers. If I could turn back the clock I would do things 100% differently, but I can’t, I just have to keep going.’

While Abi has restarted chemotherapy, she is also keen to explore alternative treatments abroad

While Abi has restarted chemotherapy, she is also keen to explore alternative treatments abroad

WHAT IS Cervical Cancer?

Cervical cancer affects the lining of the lower part of the uterus.

The most common symptom is unusual bleeding, such as between periods, during sex or after menopause, but other signs may include:

  • Pain during sex
  • Vaginal discharge that smells bad
  • Pain in the pelvis

Causes may include:

  • Age – more than half of patients are under 45 years old
  • HPV infection – which affects most people at some point in their lives
  • Smoking – responsible for 21 percent of cases
  • Birth control pill – linked to 10 percent of cases
  • Having children
  • Family history of cervical cancer or other cancers, such as the vagina

Source: Cancer Research UK

Regarding the delay to surgery experienced by Abi, a spokesperson for Swansea Bay University Health Board said: ‘We are very sorry to hear of Ms Macnamara’s concerns.

‘While the health board strives to provide the highest standard of care, the pandemic has created significant and well-documented challenges for NHS services across the UK.

‘We have not received a formal complaint from Ms Macnamara and so have not had the opportunity to conduct a thorough investigation.

‘However, we would like to have a direct conversation so that we can discuss her concerns with her in detail.’

The post Woman, 34, whose smear test was postponed during lockdown and was told not to worry when cancer diagnosis revealed her disease is now incurable appeared first on USMAIL24.COM.

]]>
https://usmail24.com/woman-34-smear-test-delayed-lockdown-told-not-worry-diagnosed-cancer-reveals-illness-incurable-htmlns_mchannelrssns_campaign1490ito1490/feed/ 0 92832
Barbara Windsor’s widower Scott Mitchell, 61, explains how ‘amazing’ romance with Tanya Franks is the ‘opposite of what dementia is’ – after soap star died from the disease aged 83 https://usmail24.com/barbara-windsor-scott-mitchell-girlfriend-tanya-franks-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/barbara-windsor-scott-mitchell-girlfriend-tanya-franks-htmlns_mchannelrssns_campaign1490ito1490/#respond Mon, 11 Mar 2024 11:45:09 +0000 https://usmail24.com/barbara-windsor-scott-mitchell-girlfriend-tanya-franks-htmlns_mchannelrssns_campaign1490ito1490/

By Ciara Farmer for Mailonline Published: 7:38 AM EDT, March 11, 2024 | Updated: 7:38 AM EDT, March 11, 2024 Barbara Windsor’s widower Scott Mitchell and his new partner Tanya Franks spoke about their romance on Monday’s episode of Lorraine. In the wake of losing his wife of 20 years in December 202083 years old, […]

The post Barbara Windsor’s widower Scott Mitchell, 61, explains how ‘amazing’ romance with Tanya Franks is the ‘opposite of what dementia is’ – after soap star died from the disease aged 83 appeared first on USMAIL24.COM.

]]>

Barbara Windsor’s widower Scott Mitchell and his new partner Tanya Franks spoke about their romance on Monday’s episode of Lorraine.

In the wake of losing his wife of 20 years in December 202083 years old, after a seven-year battle with Alzheimer’s disease, Scott, 61, explained how his “incredible friendship” with Tanya, 56, turned into a romance.

Speaking to presenters Cat Deeley and Ben Shephard, he said: ‘We have built an incredible friendship over the last four years and something wonderful has come from it…

‘The exact opposite of what dementia is. I’m lucky that I have a partner who doesn’t mind me talking about my late wife.’

Scott and Tanya have built a close friendship over the years while working together to raise awareness about Alzheimer’s disease with “Bab’s Army.”

Barbara Windsor’s widower Scott Mitchell and his new partner Tanya Franks spoke about their romance on Monday’s episode of Lorraine

Scott's wife of 20 years, Dame Barbara, died in December 2020, aged 83, after a seven-year battle with Alzheimer's disease (photo 2011)

Scott’s wife of 20 years, Dame Barbara, died in December 2020, aged 83, after a seven-year battle with Alzheimer’s disease (photo 2011)

Tanya was close to Barbara and ran the London Marathon this year as part of Bab's Army.  When Barbara passed away, she shared this photo alongside a tribute on Instagram

Tanya was close to Barbara and ran the London Marathon this year as part of Bab’s Army. When Barbara passed away, she shared this photo alongside a tribute on Instagram

Alzheimer’s disease is close to Tanya’s heart as she takes part in the London Marathon as part of Bab’s Army for her stepdad Derek.

Tanya, who knew EastEnders star Barbara and played drug-addicted prostitute Rainie Cross in the soap, admitted she could do ‘nothing but support Scott’ when discussing Barbara’s struggles and his work caring for the TV icon.

Tanya said: ‘There’s nothing I can do but support him by talking about it. You often feel alone when you care for someone with Alzheimer’s…

“The communication allowed the support system to grow. Barbara is as much about the legacy of Alzheimer’s as it is about me and my stepfather. It is hundreds of thousands that we have raised by doing the three marathons.’

Scott reiterated: ‘If anyone wants to give a million pounds for next year’s marathon, a big company or a big sponsor, I will do another marathon and shave my hair off too, and that’s the big one, shaving my hair off.’

“I don’t want people to go through the final stages of what I went through with Barbara.”

In January, Scott described Tanya as “amazing” because she “understands” that Barbara will “always have a place in my heart.”

Scott told Kaye Adams about her How to Turn 60 podcast he is “very happy” in his new relationship, with someone who is “very understanding.”

Barbara and Scott married in 2000 and their romance was controversial at the time due to their 27-year age difference (pictured in 2000)

Barbara and Scott married in 2000 and their romance was controversial at the time due to their 27 year age difference (pictured in 2000)

Tanya played crack cocaine addict as Rainie Cross in the BBC soap, where her storyline followed her and Barbara's on-screen son, Phil Mitchell

Tanya played crack cocaine addict as Rainie Cross in the BBC soap, where her storyline followed her and Barbara’s on-screen son, Phil Mitchell

He said: “She is a wonderful lady who knew Barbara. It can’t be easy being with someone who was the other half of Barbara Windsor, especially since I still put myself out there and talk about her.

“So it says to me about the type of person Tanya is that she can handle that. She is very sure of herself as a person. Just because you’re not with someone for whatever reason doesn’t mean you’re just turning off a valve of love.’

Before her relationship with Scott, Tanya was married to fellow actor James Barriscale, with whom she founded the film and theater production company Stock-pot Productions.

He played Jonathan Malnet, Jade Green’s adoptive father in the soap. Scott said his love for Barbara will always have a place in his heart.

He said, ‘Maybe I turn on the TV and suddenly she’s there and it takes my breath away sometimes because I don’t expect it.’

Scott said he began mourning Barbara on the day of her diagnosis and believes the actress would have given him and Tanya her blessing.

Barbara played Peggy Mitchell in EastEnders [pictured with her sons Grant Mitchell (Ross Kemp) and Phil (Steve McFadden) in 2016]

Barbara played Peggy Mitchell in EastEnders [pictured with her sons Grant Mitchell (Ross Kemp) and Phil (Steve McFadden) in 2016]

The post Barbara Windsor’s widower Scott Mitchell, 61, explains how ‘amazing’ romance with Tanya Franks is the ‘opposite of what dementia is’ – after soap star died from the disease aged 83 appeared first on USMAIL24.COM.

]]>
https://usmail24.com/barbara-windsor-scott-mitchell-girlfriend-tanya-franks-htmlns_mchannelrssns_campaign1490ito1490/feed/ 0 92180
What is endometriosis? A rare disease that can be a ‘silent threat’ to women’s fertility https://usmail24.com/what-is-endometriosis-a-rare-disease-that-can-be-a-silent-threat-to-womens-fertility-6777131/ https://usmail24.com/what-is-endometriosis-a-rare-disease-that-can-be-a-silent-threat-to-womens-fertility-6777131/#respond Sun, 10 Mar 2024 11:46:25 +0000 https://usmail24.com/what-is-endometriosis-a-rare-disease-that-can-be-a-silent-threat-to-womens-fertility-6777131/

At home Health What is endometriosis? A rare disease that can be a ‘silent threat’ to women’s fertility Endometriosis can increase your risk of pregnancy and delivery complications. This can be caused by the inflammation, structural damage to the uterus and hormonal influences that endometriosis causes. What is endometriosis? A rare disease that can be […]

The post What is endometriosis? A rare disease that can be a ‘silent threat’ to women’s fertility appeared first on USMAIL24.COM.

]]>

Endometriosis can increase your risk of pregnancy and delivery complications. This can be caused by the inflammation, structural damage to the uterus and hormonal influences that endometriosis causes.

What is endometriosis? A rare disease that can be a ‘silent threat’ to women’s fertility

Women should be aware of the rare disease endometriosis, which is considered a silent killer of the ovaries and a slow killer of fertility, experts warned on International Women’s Day, as March is also considered Endometriosis Awareness Month. Once a rare disease, it is now commonly diagnosed and the prevalence of endometriosis is increasing in Karnataka, experts point out.

What is endometriosis?

Endometriosis is an inflammatory condition in which endometrial tissue (tissue similar to the uterine lining) grows outside the uterus. It can cause organs such as the uterus, bladder or intestines to stick together at certain points, and this condition is called ‘adhesions’.

Dr. Usha BR, consultant, obstetrician and gynecologist, fertility and laparoscopic surgeon, Fortis Hospital, Bannerghatta Road, Bengaluru, explained that about 70 percent of women who visit the outpatient clinic with complaints of painful periods and dyspareunia are diagnosed with endometriosis. cases are asymptomatic.

“I see at least 25 cases a month. It also causes painful intercourse, leading to sexual dysfunction, interpersonal conflict and later to infertility. Endometriosis is a silent killer of the ovaries and a slow killer of fertility,” explains Dr. Usha out.

“Endometriosis, which affects 10 to 15 percent of women in their childbearing years and 70 percent of those with chronic pelvic pain, often remains obscured by misdiagnosis, prolonging unnecessary suffering,” says Dr. Ramesh B, obstetrician and gynecologist , chief laparoscopic surgeon. Endometriosis Specialist, Altius Hospital, Bengaluru.

“It usually presents as severe dysmenorrhea, manifesting as intense pain during menstruation, which is often dismissed as normal. These women endure not only physical pain, but also mental anguish, as their severe pain is often attributed to a perceived lower pain tolerance by their peers,” said Dr. Ramesh.

Symptoms and treatment

With an average diagnostic delay of 6.7 years, the journey is marred by persistent pain and compromised well-being. Early detection, especially in adolescence, offers a glimmer of hope, potentially soothing anxiety and preserving fertility, he explained.

In Bengaluru, Karnataka, as in many other regions, barriers to diagnosing and managing endometriosis persist, compounded by obstacles such as cost and complexity of symptoms.

Still, the prospect of early intervention remains a beacon of hope, promising relief from pain, halting disease progression and safeguarding fertility for women across the region, said Dr. Ramesh.

Dr. Sharvari Mundhe, Consultant, Gynecologist and Fertility Specialist, Motherhood Hospital, Sarjapur, Bengaluru, explained: “Endometriosis poses a significant health challenge for women across the world, having a significant impact on their daily lives and reproductive health. With approximately one in ten women worldwide affected by this condition, its prevalence is significant. In India alone, an estimated 25 million women struggle with endometriosis.”

Despite its widespread prevalence, endometriosis remains a confusing puzzle in the medical field, with detection during diagnosis often evaded and women left to suffer its burdensome consequences in silence, she said.

“Urgent attention is needed to develop effective treatment options, given the heavy toll this takes on physical, emotional and reproductive well-being. To enable women to better manage their symptoms and protect their reproductive health, greater investment in research, education and access to specialized treatment options is needed,” she added.

Dr. Usha said endometriosis, which affects 1 in 7 women, often manifests with pelvic pain, heavy periods and infertility. “Yet, many patients may be asymptomatic and unaware of the presence of the condition. Diagnosing endometriosis involves reviewing medical history, performing pelvic examinations and often requires laparoscopic surgery for definitive confirmation and removal of endometrial tissue outside the uterus,” she said.

Lifestyle changes, such as dietary changes and stress reduction, can complement medical treatments. Early detection and comprehensive management improve outcomes, provide relief and improve the quality of life for those affected, experts agreed.

(Input: IANS)



The post What is endometriosis? A rare disease that can be a ‘silent threat’ to women’s fertility appeared first on USMAIL24.COM.

]]>
https://usmail24.com/what-is-endometriosis-a-rare-disease-that-can-be-a-silent-threat-to-womens-fertility-6777131/feed/ 0 91657
Queen Letizia of Spain looks stylish in a navy blue knitted dress as she attends the Rare Disease Day summit in Seville https://usmail24.com/queen-letizia-spain-looks-stylish-navy-knitted-dress-attends-rare-diseases-day-summit-seville-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/queen-letizia-spain-looks-stylish-navy-knitted-dress-attends-rare-diseases-day-summit-seville-htmlns_mchannelrssns_campaign1490ito1490/#respond Tue, 05 Mar 2024 20:34:53 +0000 https://usmail24.com/queen-letizia-spain-looks-stylish-navy-knitted-dress-attends-rare-diseases-day-summit-seville-htmlns_mchannelrssns_campaign1490ito1490/

Queen Letizia of Spain triumphed in style once again as she attended an event marking Rare Disease Day in Seville, Andalusia. The 51-year-old royal chaired the country’s official event to mark World Rare Diseases Day, which was held on Tuesday, March 5, at Seville’s FIBES Conference and Exhibition Center. The former journalist wore a stylish […]

The post Queen Letizia of Spain looks stylish in a navy blue knitted dress as she attends the Rare Disease Day summit in Seville appeared first on USMAIL24.COM.

]]>

Queen Letizia of Spain triumphed in style once again as she attended an event marking Rare Disease Day in Seville, Andalusia.

The 51-year-old royal chaired the country’s official event to mark World Rare Diseases Day, which was held on Tuesday, March 5, at Seville’s FIBES Conference and Exhibition Center.

The former journalist wore a stylish knitted midi dress in navy blue from Spanish designer Galcon Studio.

The long sleeved number is known as the Floral Intarsia Knit Dress and features two large cream flowers on the front.

The elegant dress with round neck and belt at the waist is made of 100% merino wool. Once sold for €229, but is no longer available.

Pictured with Andalusian President Juanma Moreno, Queen Letizia of Spain wore a stylish knitted midi dress in navy blue by Spanish designer Galcon Studio as she attended an event to mark World Rare Disease Day in Seville on Tuesday, March 5.

Letizia wore the dress, which has a striking cream-colored floral design, a belt around the waist and wore her brown hair down

Letizia wore the dress, which has a striking cream-colored floral design, a belt around the waist and wore her brown hair down

As honorary president of the Spanish Federation of Rare Diseases (FEDER), which celebrates its 25th anniversary this year, Queen Letizia addressed the audience

As honorary president of the Spanish Federation of Rare Diseases (FEDER), which celebrates its 25th anniversary this year, Queen Letizia addressed the audience

Eagle-eyed royal fans may recognize the dress from previous official engagements, including Ateneo De Madrid’s bicentenary last April.

Before that, the mother of two wore the garment in March 2022 for the start of the ‘Talent Tour’ in Malaga.

In Seville she paired the dress with black patent leather shoes and diamond studs in the shape of a star, while her straight brown hair fell just below her shoulders.

While this year’s World Day for Rare Diseases took place on February 29, in Spain it was officially celebrated on March 5.

Also present were Andalusian President Juanma Moreno, Spanish Health Minister Monica Garcia and President of the Spanish Federation of Rare Diseases (FEDER) Juan Carrion.

FEDER, which campaigns for research and treatments for rare diseases, was founded 25 years ago in Seville.

Letizia, honorary president of the organization, last visited FEDER on February 13, where she also showed off her fashion flair.

She beamed as she arrived at the organization’s headquarters in Madrid, the Spanish capital.

Letizia had previously worn the elegant long-sleeved dress from Galcon Studio to previous official engagements, including the bicentenary of Ateneo De Madrid last April

Letizia had previously worn the elegant long-sleeved dress from Galcon Studio to previous official engagements, including the bicentenary of Ateneo De Madrid last April

The royal family was pictured smiling next to Andalusian President Juanma Moreno

The royal family was pictured smiling next to Andalusian President Juanma Moreno

The 51-year-old former journalist paired her dress with black patent leather shoes and diamond studs in the shape of a star

The 51-year-old former journalist paired her dress with black patent leather shoes and diamond studs in the shape of a star

Letizia chaired the event, which took place at Seville's FIBES Conference and Exhibition Center

Letizia chaired the event, which took place at Seville’s FIBES Conference and Exhibition Center

The royal made a stylish entrance in a striking chartreuse blazer from Hugo Boss, priced at £354.99, paired with wide-leg trousers and suede boots.

Letizia’s ‘Jestena’ coat debuted in November 2023 and is made from textured wool with an asymmetrical double-breasted front and classic notched lapels.

Every year she visits FEDER to find out more about the challenges and opportunities the charity expects for the year ahead.

She let her jacket take center stage and complemented it with wide-leg trousers, suede boots and a long wool coat – all in a sleek black shade.

The royal opted for her signature makeup look, with a smoky eye, bronzed cheekbones and nude lip, while her brunette locks fell over her shoulders.

Letizia completed her ensemble with minimal jewelry, opting only for diamond stud earrings and a gold ring.

FEDER helps people who have contracted a disease that affects fewer than five in 10,000 people. In Spain alone there are more than three million people who meet these requirements.

The post Queen Letizia of Spain looks stylish in a navy blue knitted dress as she attends the Rare Disease Day summit in Seville appeared first on USMAIL24.COM.

]]>
https://usmail24.com/queen-letizia-spain-looks-stylish-navy-knitted-dress-attends-rare-diseases-day-summit-seville-htmlns_mchannelrssns_campaign1490ito1490/feed/ 0 88570
Apparently healthy, but diagnosed with Alzheimer’s disease? https://usmail24.com/alzheimers-amyloid-diagnosis-html/ https://usmail24.com/alzheimers-amyloid-diagnosis-html/#respond Mon, 04 Mar 2024 17:31:08 +0000 https://usmail24.com/alzheimers-amyloid-diagnosis-html/

Determining whether someone has Alzheimer’s disease usually requires an extensive diagnostic process. A doctor takes a patient’s medical history, discusses symptoms, and administers verbal and visual cognitive tests. The patient may undergo a PET scan, an MRI or a spinal tap – tests that detect the presence of two proteins in the brain, amyloid plaques […]

The post Apparently healthy, but diagnosed with Alzheimer’s disease? appeared first on USMAIL24.COM.

]]>

Determining whether someone has Alzheimer’s disease usually requires an extensive diagnostic process. A doctor takes a patient’s medical history, discusses symptoms, and administers verbal and visual cognitive tests.

The patient may undergo a PET scan, an MRI or a spinal tap – tests that detect the presence of two proteins in the brain, amyloid plaques and tau tangles, both associated with Alzheimer’s disease.

All this could change dramatically if the new criteria, proposed by a working group of the Alzheimer’s Association, become widely accepted.

The final recommendations, expected later this year, will accelerate a shift that is already underway: from defining the disease by symptoms and behavior, to defining it purely biologically – with biomarkers, substances in the body that indicate disease.

The design guidelines, Revised criteria for diagnosis and staging of Alzheimer’s disease, argues for a simpler approach. That could mean a blood test to show the presence of amyloid. Such tests are already available in some clinics and doctors’ offices.

“Someone with biomarkers that show amyloid is present in the brain has the disease, whether it is symptomatic or not,” said Dr. Clifford R. Jack Jr., chair of the task force and a researcher in the disease field. Alzheimer’s at the Mayo Clinic.

“The pathology exists years before the symptoms appear,” he added. “That’s science. It is irrefutable.”

He and his colleagues on the panel recommend against testing people who have no symptoms of cognitive decline. But skeptics predict this is likely to happen anyway. If so, a significant proportion would test positive for amyloid and therefore be diagnosed with Alzheimer’s.

a 2015 Dutch study It is estimated that more than 10 percent of cognitively normal 50-year-olds would test positive, as would almost 16 percent of 60-year-olds and 23 percent of 70-year-olds. Most of these people would never develop dementia.

A number of experts and interested parties however, remain unconvinced by the argument for turning to biomarkers alone. The American Geriatrics Society has done just that called the proposed criteria “premature” – and pointed out the high percentage of panel members with ties to the pharmaceutical and biotechnology industries, creating potential conflicts of interest.

“This is a leap forward of at least five to ten years,” says Dr. Eric Widera, a geriatrician at the University of California, San Francisco, and author of a sharply critical book. editorial in the Journal of the American Geriatrics Society.

Some background: The panel undertook this effort just five years after issuing the last diagnostic guidelines, because “two major events really required a revision,” said Dr. Jack.

First, the best amyloid blood tests proved to be highly accurate, less invasive than spinal taps and much cheaper than brain scans. In addition, aducanumab (brand name: Aduhelm) and lecanemab (Leqembi), two drugs that remove amyloid from the brain, received regulatory approval, but not without intense controversy.

Research has shown that the drugs have a modest but statistically significant ability to slow the progression of symptoms for 18 months in people with mild cognitive impairment or mild Alzheimer’s disease. (The drugmaker Biogen is withdrawing aducanumab, but other amyloid-reducing drugs are in the pipeline.)

Are these developments enough to justify the possibility of diagnosing healthy people with irreversible disease, based on a blood test that detects amyloid? Some doctors have already made such requests.

Diagnosing Alzheimer’s disease before symptoms emerge could enable yet-to-be-developed treatments to prevent the memory loss, impaired judgment and eventual dependency that the disease causes. Doctors diagnose many diseases, including diabetes and cancer, with tests on asymptomatic people.

But how many of those with amyloid in the brain (most of whom will also have tau deposits) will eventually develop dementia? “The answer, unfortunately, is that it depends,” said Dr. Jack.

The Mayo Clinic Research on Aging followed nearly 5,000 cognitively normal older adults in a Minnesota county for an average of 9.4 years. It found high rates of dementia among those who carried the APOE4 gene, which is associated with an increased risk of Alzheimer’s disease.

For those who were 65 and had high amyloid levels, the estimated lifetime risk of dementia was 74 percent for women and 62 percent for men.

But only 15 to 25 percent of people carry that gene, according to the National Institute on Aging. Among participants who did not, both men and women aged 65 years had an estimated risk of dementia of about 55 percent at high amyloid levels and 36 percent at moderate levels.

“Because mortality rates among the elderly are high, many will die before developing dementia,” said Dr. Jack.

Dr. Jason Karlawish, a geriatrician and co-director of the Penn Memory Center in Philadelphia, said he considers amyloid a risk factor, just as smoking is a risk factor for cancer.

“But I think the evidence is still not clear and convincing that amyloid alone defines Alzheimer’s disease.”

Two large trials of amyloid-reducing drugs in cognitively normal people, expected to be completed in 2027 and 2029, could provide such evidence if they can show that removing amyloid prevents, halts or reverses cognitive decline in that age group.

For now, the proposed guidelines are “simply not ready for clinical practice,” said Dr. Karlawish.

As regards the working groupAbout a third of the 22 members work at companies that develop drugs and diagnostics, according to their disclosures. About another third disclose research grants or contracts, consulting fees, honoraria, or other payments from industry sources.

“They will directly benefit from this change,” said Dr. Widera. He pointed to estimates that 40 million cognitively normal Americans could test positive for amyloid, be diagnosed with Alzheimer’s disease and possibly start taking off-label medications, despite there being no evidence yet that the drugs be effective in asymptomatic people.

“These are not benign drugs,” added Dr. Widera added. “You will have to take these drugs for the rest of your life – just like a statin, but much more expensive and much more dangerous.” Aducanumab and lecanemab can cause brain hemorrhages and reduce brain volume, side effects that are not uncommon.

Dr. Widera further criticized the working group’s proposal not to discuss the harms of the new criteria – including unnecessarily frightening people who are unlikely to develop dementia and potentially causing discrimination in employment and insurance.

Dr. Jack, who has reported no conflicts of interest, defended his working group. “The members are committed to accurately representing what current science says,” he said. “No commercial gain was taken into account. Everyone was focused on what is best for the patients.”

However, numerous studies have shown that industry payments and sponsorships even for cheap meals, have measurable influence. They are associated with doctors more likely to prescribe promoted medicationsand with more favorable research results when manufacturers sponsor studies of drugs and medical devices.

A lot of patient advocacy groupsincluding the Alzheimer’s Association, also have ties to the industry.

Often, redefining diseases or revising guidelines means lowering thresholds and broadening classifications, also known as ‘diagnosis creep’. The thresholds for high blood pressure and high cholesterol are now lower than, for example, in previous years. New precursor conditions such as prediabetes are also increasing the number of people defined as having a disease.

With amyloid testing as a benchmark, “there will be a new Alzheimer’s disease pandemic,” Dr. Widera. “There will be a big push for early detection.”

Part of that impetus may come from the patients themselves. “We are in an information age where people are interested in knowing more about their current and future health,” says Dr. Gil Rabinovici, a neurologist who directs the Alzheimer’s Disease Research Center at the University of California, San Francisco.

Early diagnosis of Alzheimer’s disease could lead to lifestyle changes — quitting smoking, exercising, improving diet — that could still have “a protective effect,” he said.

“Personally, I wouldn’t want to know if I had plaques in my brain,” he added. And he wouldn’t prescribe amyloid drugs to patients without symptoms, he said, until further research showed effectiveness in that cohort.

Still, we have “moved away from the idea that the doctor decides who learns what,” he said, adding that after thorough counseling “if I am convinced that I am not going to harm them and I feel that they can get the information understand what they get’. I’m not going to refuse to offer them a test.”

The post Apparently healthy, but diagnosed with Alzheimer’s disease? appeared first on USMAIL24.COM.

]]>
https://usmail24.com/alzheimers-amyloid-diagnosis-html/feed/ 0 87791
Scientists may have finally found the cause of the long Covid-19 virus: low iron levels after infection ‘could be a cause of a poorly understood disease’ https://usmail24.com/scientists-finally-cause-long-covid-low-iron-levels-infection-trigger-poorly-understood-illness-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/scientists-finally-cause-long-covid-low-iron-levels-infection-trigger-poorly-understood-illness-htmlns_mchannelrssns_campaign1490ito1490/#respond Mon, 04 Mar 2024 17:18:22 +0000 https://usmail24.com/scientists-finally-cause-long-covid-low-iron-levels-infection-trigger-poorly-understood-illness-htmlns_mchannelrssns_campaign1490ito1490/

In Britain alone, 1.9 million people say they are experiencing symptoms of long Covid-19 Scientists found that people with long Covid-19 had problems with iron levels in the blood By Xantha Leatham, deputy science editor of The Daily Mail Published: 09:51 EST, March 4, 2024 | Updated: 12:03 EST, March 4, 2024 Experts may have […]

The post Scientists may have finally found the cause of the long Covid-19 virus: low iron levels after infection ‘could be a cause of a poorly understood disease’ appeared first on USMAIL24.COM.

]]>
  • In Britain alone, 1.9 million people say they are experiencing symptoms of long Covid-19
  • Scientists found that people with long Covid-19 had problems with iron levels in the blood

Experts may have identified the cause of the long Covid-19 virus after discovering that low iron levels after an infection could be a major trigger.

In Britain alone, an estimated 1.9 million people say they are experiencing symptoms of long Covid-19.

These can include fatigue, shortness of breath, muscle pain and problems with memory and concentration – and can persist long after the initial Covid infection has cleared.

Now scientists believe that problems with iron levels in the blood – and the body’s ability to regulate this important nutrient – ​​may be a major cause of persistent problems.

And the discovery could point to possible ways to prevent or treat the condition.

In Britain alone, an estimated 1.9 million people say they are experiencing symptoms of long Covid-19. These symptoms may include fatigue, muscle pain, and loss of smell

Shortly after the start of the pandemic, a team led by Cambridge University began recruiting people who had tested positive for the virus.

Over the course of a year, participants provided blood samples and it became clear that a significant number of patients would continue to have symptoms.

What is long Covid?

Most people with Covid feel better within a few days or weeks, but those with long Covid-19 take much longer to recover.

The symptoms include:

Fatigue, shortness of breath, loss of smell and muscle pain.

It can also lead to:

Memory problems, tightness in the chest, insomnia, palpitations, dizziness, joint pain, tingling, ringing in the ears, abdominal pain, loss of appetite, high temperature, coughing, rash and depression.

Source: NHS

Ultimately, the researchers focused their analysis on 214 people, about half of whom reported long-lasting Covid symptoms between three and 10 months after their infection.

They found that persistent inflammation and low blood iron levels could be observed as early as two weeks after an infection in individuals who reported a long Covid-19 epidemic many months later.

Problems with blood iron levels were detectable in the long Covid group, regardless of age, gender or severity of infection, they found.

Dr. Aimee Hanson, who worked on the study while at the University of Cambridge and now works at the University of Bristol, said: ‘Iron levels and the way the body regulates iron were disrupted early on during the SARS-CoV-2 -infection. and it took a very long time to recover, especially in those people who reported long Covid symptoms months later.

‘Although we saw evidence that the body was trying to correct low iron availability and resulting anemia by producing more red blood cells, it did not do so particularly well in the face of ongoing inflammation.’

Co-author Professor Hal Drakesmith, from the University of Oxford, said iron dysregulation is a natural response to infection.

“When the body has an infection, it responds by removing iron from the bloodstream,” he said.

‘This protects us from potentially deadly bacteria that capture the iron in the bloodstream and grow rapidly. It is an evolutionary response that redistributes iron in the body, and the blood plasma becomes an iron desert.

Researchers found that persistent inflammation and low blood iron levels could be seen as early as two weeks after an infection in individuals who reported long Covid many months later.

Researchers found that persistent inflammation and low blood iron levels could be seen as early as two weeks after an infection in individuals who reported long Covid many months later.

‘However, if this continues for a long time, there is less iron for the red blood cells, which means oxygen is transported less efficiently, which affects metabolism and energy production, and for the white blood cells, which need iron to work properly. The protective mechanism eventually becomes a problem.’

The findings, published in the journal Nature Immunology, may help explain why symptoms such as fatigue and exercise intolerance are common in long Covid.

The researchers say the study points to possible ways to prevent or reduce the impact of long Covid-19 by correcting iron dysregulation during early infections.

One approach might be to control the extreme inflammation as early as possible, before it impacts iron regulation.

Another approach could include iron supplementation, but as Dr. Hanson noted, this may not be easy.

“It’s not necessarily that people don’t have enough iron in their bodies, it’s just that it’s stuck in the wrong place,” she said.

“What we need is a way to remobilize the iron and get it back into the bloodstream, where it becomes more useful to the red blood cells.”

The post Scientists may have finally found the cause of the long Covid-19 virus: low iron levels after infection ‘could be a cause of a poorly understood disease’ appeared first on USMAIL24.COM.

]]>
https://usmail24.com/scientists-finally-cause-long-covid-low-iron-levels-infection-trigger-poorly-understood-illness-htmlns_mchannelrssns_campaign1490ito1490/feed/ 0 87787