fueled – USMAIL24.COM https://usmail24.com News Portal from USA Fri, 23 Feb 2024 01:44:07 +0000 en-US hourly 1 https://wordpress.org/?v=6.4.4 https://usmail24.com/wp-content/uploads/2024/01/Untitled-design-1-100x100.png fueled – USMAIL24.COM https://usmail24.com 32 32 195427244 Roger Guillemin, 100, Nobel Prize winner, fueled by rivalry, dies https://usmail24.com/roger-guillemin-dead-html/ https://usmail24.com/roger-guillemin-dead-html/#respond Fri, 23 Feb 2024 01:44:07 +0000 https://usmail24.com/roger-guillemin-dead-html/

Roger Guillemin, a neuroscientist who co-discovered the unexpected hormones that the brain uses to control many bodily functions, died Wednesday at a retirement home in San Diego. He was 100. His death was confirmed by his daughter Chantal. The career of Dr. Guillemin was marked by two spectacular competitions that turned the staid world of […]

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Roger Guillemin, a neuroscientist who co-discovered the unexpected hormones that the brain uses to control many bodily functions, died Wednesday at a retirement home in San Diego. He was 100.

His death was confirmed by his daughter Chantal.

The career of Dr. Guillemin was marked by two spectacular competitions that turned the staid world of endocrinological research upside down. The first was a decade-long battle with his former partner, Andrew V. Schallythat ended in a draw when the two shared half Nobel Prize in Physiology or Medicine in 1977. (The other half went to American medical physicist Rosalyn Yalow for unrelated research.)

The second match began shortly thereafter when Wylie Vale Jr., Dr.’s longtime associate and protege. Guillemin, set up a rival laboratory on the same campus of the Salk Institute for Biological Studies in San Diego where both men worked, leaving Dr. a new period of intense scientific struggle.

Roger Charles Louis Guillemin (pronounced with a hard g: GEE-eh-mah) might have pursued a quiet career as a general practitioner in the French city of Dijon, the capital of Burgundy, where he was born on January 11, 1924 and where he attended public schools and then to medical school. But a chance meeting with Hans Selyean expert on the body’s response to stress, took him to Montreal, where he was introduced to medical research at Dr. Selye at the University of Montreal.

There he became interested in a leading problem of the time: the way the brain controls the pituitary gland, the master organ that controls the production of the body’s other major glands.

The pituitary gland is located in a small bone sac just below a central brain area called the hypothalamus. No one could find nerves connecting the hypothalamus to the pituitary gland, so a fallback suspicion was that the hypothalamus might control the pituitary gland with hormones. But many biologists refused to believe that the brain could produce hormones as a mere gland.

The postulated hormones were called ‘releasing factors’ because they were shown to cause the pituitary gland to release its own hormones.

In 1954, Dr. Guillemin made a critical observation: pituitary cells grown in glassware would not produce hormones unless cells of the hypothalamus were cultured with them. The finding supported the idea of ​​letting go of factors, and Dr. Guillemin was determined to prove this. He moved to Baylor College of Medicine in Houston, where he attempted to isolate the putative releasing factors from the hypothalami of cattle killed in a kosher slaughterhouse.

Success eluded him and in 1957 he teamed up with another young researcher, Andrzej V. Schally, better known as Andrew. The two worked together for five years, but mysterious unleashing factors thwarted their best efforts. The partnership is broken. Dr. Schally moved to the Veterans Affairs Hospital in New Orleans. Dr. Guillemin eventually hired two key researchers at Baylor – Dr. Vale as a physiologist and Roger Burgus as a chemist – who would form the mainstay of his efforts over the next decade.

Dr. Guillemin and Dr. Schally worked independently and both decided that they needed much larger numbers of hypothalami to extract sufficient amounts of releasing factor. Each of them turned his laboratory into a semi-industrial processing plant, aided by liberal government research funds that became available after the Soviet Union launched Sputnik, the first artificial space satellite, in 1957. Dr. Guillemin eventually processed more than two million sheep hypothalami, and Dr. Schally worked on the same scale with pig brains.

The rivalry between the two teams was intense, especially in the area of ​​scientific credit. “Let me remind you too,” wrote Dr. Schally to Dr. Guillemin in a letter in 1969, “to your deliberate, repeated and personal scientific attacks against me, as well as to your continued failure to recognize our contributions.”

Dr. Schally later told an interviewer, “I could have been an equal partner with him, but he wanted me to be his slave.”

The releasing factors exist in such small quantities in the brain that they were barely detectable with the techniques of the time. A single fingerprint on glassware contained enough amino acids – the components of the releasing factors – to ruin an entire experiment. After another seven years of effort, neither Dr. Guillemin, nor Dr. Schally isolated a liberating factor. Other researchers said the government, which has funded the two men’s work for years, should stop wasting its money. There was more evidence of the Loch Ness Monster, they said.

In 1969, the committee of scientists advising the National Institutes of Health on endocrinological research convened a meeting to prepare to end support for the two laboratories. But a few days before the meeting, Dr. Burgus made a significant advance in identifying the chemical structure of the releasing factor that controls the thyroid gland via the pituitary gland. Within a few months, Schally and Guillemin’s teams had fully identified the releasing factor known as TRF and the funding disruption was averted.

A race now began to find a second releasing factor, FRF, which controlled the body’s reproductive systems. The team of Dr. Schally narrowly came in first place, but Dr. Guillemin then recovered by discovering a releasing factor involved in the control of the body’s growth.

Dr. Guillemin succeeded because he had identified a crucial problem that he and Dr. Schally had pursued against all odds, while better-known researchers had failed. The identification of the releasing factors was a major event in medicine, and the Nobel Committee in Stockholm awarded the prize for this achievement.

Dr. Guillemin had little time to rest on his laurels. His research team had become disenchanted with his relentless quest for scientific glory. Dr. Vale later complained about “what hell it can sometimes be for people who get caught in the meat grinder and take out more and more meat. glory for Guillemin, especially if you are the meat.

Dr. Vale founded his own laboratory at the Salk Institute in 1977 (Dr. Guillemin had founded one in 1970), and endocrinologists were treated to the spectacle of yet another raging rivalry, this time between Dr. Guillemin and his protégé. They competed to find the releasing factors known as CRF, which is involved in stress, and GRF, which stimulates growth. Both succeeded, although Dr. Vale was the first in both cases.

Dr. Guillemin married Lucienne Jeanne Billard in 1951, who had been his nurse during a near-fatal attack of tuberculous meningitis in Montreal. In addition to his daughter Chantal, he is survived by four other daughters: Claire, Hélène, Elisabeth and Cece; a son, François; and four grandchildren. His wife died in 2021, also at 100.

Dr. Guillemin and Dr. Vale later reconciled and became good friends. In a tribute to the 65th birthday of Dr. Vale quoted Dr. Guillemin, well aware of the irony of competing with his ‘scientific son’, Freud’s analysis of the Oedipus myth: ‘A part of every son worth his salt plans to kill the father he loves and who takes over his kingdom.”

Kellina Moore contributed reporting.

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Isiah Pacheco is furious and has fueled the Chiefs' rushing attack in the playoffs https://usmail24.com/isiah-pacheco-chiefs-offense-nfl-playoffs/ https://usmail24.com/isiah-pacheco-chiefs-offense-nfl-playoffs/#respond Thu, 25 Jan 2024 21:34:10 +0000 https://usmail24.com/isiah-pacheco-chiefs-offense-nfl-playoffs/

KANSAS CITY, Mo. – His hands clenched into fists and his biceps flexed. Running back Isiah Pacheco stomped down the Kansas City Chiefs sideline, his message punctuated by his demonstrative voice. “Ay, bring that damn energy!Pacheco shouted to his attacking teammates, many of whom nodded in agreement. “Bring that s-! Bring that s-!” A few […]

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KANSAS CITY, Mo. – His hands clenched into fists and his biceps flexed. Running back Isiah Pacheco stomped down the Kansas City Chiefs sideline, his message punctuated by his demonstrative voice.

Ay, bring that damn energy!Pacheco shouted to his attacking teammates, many of whom nodded in agreement. “Bring that s-! Bring that s-!

A few minutes later, the Chiefs began the second half of their divisional round playoff game against the Buffalo Bills, the first time Pacheco had played in a road elimination game in his young, two-year career. Trailing the Chiefs by four points, Pacheco helped them score touchdowns on back-to-back drives by doing what has made him one of the NFL's most distinctive players: every time he touched the ball, he ran with anger, intensity and brutality.

Pacheco's running style was instrumental in the Chiefs' advance to the AFC Championship Game for the sixth straight season. He led all players with 97 rushing yards on 15 attempts, a significant number of those yards gained after the first defender made contact with him.

Sixty percent of Pacheco's carries ended with him going over the expected distance, according to NFL Next Gen Stats, the highest percentage of all qualified running backs in the divisional round.

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As Pacheco entered the end zone early in the fourth quarter on his 4-yard touchdown run, which turned out to be the winning score, he called another message to leave Donovan Smith and Travis Kelce behind.

They can't come with us!Pacheco said. He continued to encourage his teammates as he reached the sideline, saying:Everything you have! Everything you have!

In the Chiefs' two postseason victories, over the Bills and Miami Dolphins, Pacheco has backed up his words with dominant performances.

His teammates have also taken their play to the next level. The Chiefs' rushing attack, an area of ​​the offense that was inconsistent at times during the regular season, was exceptional in the playoffs. The offensive linemen – Smith, left guard Joe Thuney, center Creed Humphrey, right guard Trey Smith, right tackle Jawaan Taylor and backup guard Nick Allegretti – were the superior group in the trenches. And the Chiefs' three tight ends — Kelce, Noah Gray and Blake Bell — have all improved their blocking.

“I'm proud of how resilient the boys have been,” Humphrey said. “We've had a bit of a slump, but the boys kept pushing and we've improved, which is really good to see.”

Entering the playoffs, offensive coordinator Matt Nagy and quarterback Patrick Mahomes recognized that the Chiefs offense would need a simpler approach to limit mistakes in the postseason. The easiest way for coach Andy Reid and Nagy to accomplish that was to give Pacheco a bigger role in the offense by increasing his workload. Pacheco's 39 rushing attempts in the playoffs are the most he has had in a two-game span this season. He's been effective with those touches, too, producing 186 yards and two touchdowns — and eight rushes of 8 yards or more.

“I thought we did a good job with opportunities during the (regular season), but (offensive line coach) Andy Heck does a great job designing the runs, and the guys executed them,” Reid said. “The offensive line takes a lot of pride in what they do. They know it starts with them and they have been very precise with their blocking orders.”

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Even in the fourth-coldest game in NFL history, with a temperature of minus-4 degrees at kickoff at Arrowhead Stadium against the Dolphins, Pacheco still ran the ball with rugged aggression through multiple defenders, including his three-yard touchdown. His highlights prompted many fans on social media to make exaggerated comparisons when they saw him perform.

Before Wednesday's practice, Pacheco shared his favorite.

“The funniest thing to me was when they said I run like I bite people,” Pacheco said, smiling and laughing. 'I'm not a zombie. That was crazy. It's a great opinion to have, I think. For me it just means being determined and understanding that I have a goal to achieve.”

Just a month ago, Pacheco missed two games as he suffered another right shoulder injury, the same shoulder he injured during the Chiefs' postseason run last year. He underwent what Reid described as a “clean-up surgery,” an arthroscopic procedure, before returning to the lineup on Christmas Day.

Since then, Pacheco has adjusted his post-practice routine so that he receives as much treatment as possible from the team's medical staff.

“Last year was the longest season of my career, so understanding that this is the second year, there was no offseason for me,” Pacheco said. “I had surgery, so it's been an ongoing process. I (stayed) longer in the building because I was one of the last to leave.”

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Pacheco did not participate in practice on Wednesday due to a sprained toe, a decision Reid made as a precaution. Pacheco expects to play Sunday against the Baltimore Ravens and understands he could have 20 carries against the NFL's top-ranked defense, which has allowed just 16.3 points per game.

“It's very important to protect the ball,” said Pacheco, who has fumbled just once in five postseason games. “That's the biggest part of the game, knowing the team knows you're going to play it.”

Pacheco knows the ideal situation for him and the offensive linemen for Sunday's game: a final drive in the fourth quarter, where the mission is to get the first down that would secure a victory and send the Chiefs to Super Bowl LVIII to steer.

After Bills kicker Tyler Bass missed a potential tying 44-yard field goal after the two-minute warning Sunday, the Chiefs still needed to get a first down to exhaust all of their opponent's timeouts. Pacheco ran through two defenders and gained 8 yards on the first down. The Chiefs got the final play first on the next play, a three-yard run up the middle from Pacheco.

“That's what you want to do in that situation, let the coaches put it on our shoulders up front,” Humphrey said of the offensive line. “I'm really proud of the way the boys executed these two plays. Pop running really fast was also great to see.”

Pacheco's last two rushing attempts were similar to his previous thirteen in the game, full of determination, ferocity and hostility.

Before Pacheco left the stage Wednesday, a reporter asked a question he's heard before: Is that you? Real angry when you run with the ball?

“Absolute!” Pacheco responded quickly. “I'm willing to do whatever it takes to get the job done.”

(Photo: Kathryn Riley/Getty Images)

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Bitcoin plummets below $25,000 amid massive sell-off fueled by fears of skyrocketing interest rates https://usmail24.com/bitcoin-plummets-25-000-amid-huge-selloff-sparked-fear-rocketing-rates-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/bitcoin-plummets-25-000-amid-huge-selloff-sparked-fear-rocketing-rates-htmlns_mchannelrssns_campaign1490ito1490/#respond Wed, 07 Jun 2023 17:57:52 +0000 https://usmail24.com/bitcoin-plummets-25-000-amid-huge-selloff-sparked-fear-rocketing-rates-htmlns_mchannelrssns_campaign1490ito1490/

Bitcoin plummeted to its lowest point since 2020 on Monday after major US cryptocurrency lending company Celsius Network froze withdrawals and transfers citing “extreme” conditions, in the latest sign of how turbulence in financial markets is causing turmoil in the cryptosphere. The move to freeze withdrawals at Celsius Network on Sunday triggered a drop in […]

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Bitcoin plummeted to its lowest point since 2020 on Monday after major US cryptocurrency lending company Celsius Network froze withdrawals and transfers citing “extreme” conditions, in the latest sign of how turbulence in financial markets is causing turmoil in the cryptosphere.

The move to freeze withdrawals at Celsius Network on Sunday triggered a drop in cryptocurrencies, with their value falling below $1 trillion on Monday for the first time since January last year, with the largest token bitcoin dropping 11 percent.

Following the Celsius announcement, Bitcoin hit an 18-month low of $23,476. No.2 token ether fell a whopping 16% to $1,177.

On Monday, Binance, the world’s largest cryptocurrency exchange, also halted withdrawals, blaming “transaction stuck” causing a backlog of transactions.

Binance CEO Changpeng Zhao said the halt to withdrawals would last only half an hour, but the system has already been down for an hour and a half at 10:30am.

Bitcoin hit an 18-month low of $23,476. No.2 token ether fell a whopping 16% to $1,177, the lowest since January 2021

Experts say this is a milestone for the digital phenomenon and have advised against reinvesting during the current downturn

Experts say this is a milestone for the digital phenomenon and have advised against reinvesting during the current downturn

Cryptocurrencies have plummeted across the board on news that US inflation continues to rise

Cryptocurrencies have plummeted across the board on news that US inflation continues to rise

Cryptomarkets have taken a dive in recent weeks as rising interest rates and rising inflation hurt riskier assets in the financial markets. The May collapse of the terraUSD and luna tokens also shook the industry.

“It’s still an awkward moment, and there’s some contagion risk around crypto more broadly,” said Joseph Edwards, head of financial strategy at fund management firm Solrise Finance.

Celsius offers interest-bearing products to customers who deposit cryptocurrencies on its platform and then lend cryptocurrencies to earn a return.

In a blog post, the company said it had frozen withdrawals and transfers between accounts “to stabilize liquidity and operations as we take steps to preserve and protect assets.”

“We are taking this action today to put Celsius in a better position to meet its withdrawal obligations over time,” the New Jersey-based company said.

Cryptocurrency markets are crashing all over the world with people cashing out due to post-pandemic inflation and rising cost of living

Cryptocurrency markets are crashing all over the world with people cashing out due to post-pandemic inflation and rising cost of living

The surge in interest in crypto lending has raised concerns from regulators, especially in the United States, who are concerned about investor protection and the systemic risks of unregulated lending products.

David Gerard, an author and crypto expert, said a lack of regulation has doomed the industry. Anyone who started investing in crypto in the past six months has been sold “magic beans” instead.

You can’t get rich for free. You would think that was obvious, but people keep hoping that there is a way out and that they will move forward, but it’s always false hope,” he said. “Some people are doing great, but more people are dying.”

Celsius and crypto companies that offer services similar to banks are in a “grey area” of regulation, said Matthew Nyman of law firm CMS. “They are not subject to any clear regulation requiring disclosure” about their assets.

Celsius CEO Alex Mashinsky and Celsius did not immediately respond to Reuters requests for comment outside of U.S. business hours.

Experts agree that this is a dark time for the digital currency and have warned investors to stay away from the stock during the current crisis – they predict prices will fall by another 50 percent.

Bitcoin looks poised to crash to $20K and Ethereum to $1K. If so, the total market capitalization of nearly 20,000 digital tokens would drop below $800 billion, from nearly $3 trillion at its peak,” said Chief Economist & Global Strategist at Europac Peter Schiff.

Don’t buy this dip. You lose a lot more money.’

Schiff told MailOnline that falling stock prices are a result of skyrocketing inflation and the cost of living following Friday’s announcement that US inflation rose to 8.6 percent.

“With food and energy prices rising, many Bitcoin HODLers will be forced to sell to cover costs. Supermarkets and gas stations do not accept Bitcoin. When Bitcoin crashed during Covid, no one had to sell,” the global economist said, using the slang for Bitcoin investor.

‘Consumer prices were much lower and HODLers received stimulus checks. The need to sell Bitcoin to pay the bills will only get worse as the recession deepens and many HODLers lose their jobs, especially those working for soon-to-be-bankrupt blockchain companies.

“If conditions change, long-term buyers without pay will be forced to sell.”

HODLers is a crypto slang term to describe a strategy used by buy-and-hold traders, rather than people who buy and sell at every dip.

It’s been a short honeymoon for Celsius.

The cryptocurrency lender raised $750 million in funding from investors including Canada’s second largest pension fund, Caisse de Dépôt et Placement du Québec, at the end of November. Celsius was valued at $3.25 billion at the time.

As of May 17, Celsius had $11.8 billion in assets, the website said, down more than half from October, and had processed a total of $8.2 billion in loans.

Mashinsky, the CEO, was quoted last October as saying that Celsius had more than $25 billion in assets.

The company’s website, which urges customers to “earn high.” Borrowing low,” said it offers interest rates of up to 18.6%.

Rival cryptocurrency lender Nexo said Monday it had offered to buy Celsius’s outstanding assets.

“We contacted Celsius on Sunday morning to discuss the acquisition of the collateralized loan portfolio. So far, Celsius has chosen not to participate,” says Nexo co-founder Antoni Trenchev.

Celsius did not immediately respond to a request for comment on Nexo’s offer.

Cryptocurrency investors face mental health issues as its value plummets

It was one of the world’s largest cryptocurrencies, but after a coordinated attack on its systems, Terra Luna is now worthless.

Not only did the financial carnage leave thousands of eager investors pouring millions out of their pockets, it also sent many into dark mental health holes — some so bad that they even attempted suicide.

Others were forced to hide in their homes while their friends furiously tried to confront them by pounding on their doors demanding answers and retribution.

On the subreddit for TerraLuna, the main discussion site for the self-proclaimed “LUNAtics,” a terrified investor asked for advice today.

“My friends I recommended Luna all hate me now,” they wrote.

“Lots of angry calls and loud knocks on my door from former friends who told me to buy Luna early, I feel like we’ve all lost our savings and they have kids. What shall I do?’

Terra Luna, once one of the world’s top pair of cryptocurrencies, began to falter on May 8, with many investors cutting their losses and selling their coins.

Similar to a run on the banks, the sell-off triggered a death spiral, rendering the cryptocurrency worthless.

TerraUSD, a stablecoin system, has always been pegged to the US dollar in an effort to create stability and security for investors.

The sudden collapse of both Terra and Luna, which wiped out billions of its value, not only angered investors, it left many wrestling with suicidal thoughts.

“I’ve lost over $450,000, I can’t pay the bank. Soon I will lose my house. I will become homeless. Suicide is the only way out for me,” one person wrote.

“I am going through some of the darkest, most severe mental anguish of my life. It still doesn’t really seem like I’ve lost $180,000… If I get through this, I’ll be stronger than ever,” added another.

“Bro, my little brother lost his entire net worth of £350,000, so gone. I lent him 5k and he moved in with me,” a third wrote.

In another post-crash story, an investor begged people to seek mental health care after their own friend attempted to take his own life.

“My friend and ex-colleague (my manager for 15 years) attempted suicide this morning. He basically moved all of his savings to crypto in 2021 and LUNA was a huge player in his portfolio,” they wrote.

“I just wanted to tell you – if you feel pain and you think your life is miserable without money, you feel failure and everything… just come to the people you love.”

Don’t be alone, this is getting serious. Do not overestimate the value of money, life has a much higher value. I don’t post on Reddit at all, but I thought it was important to do it now. Wish you luck.’

A third told his own story of surviving a suicide attempt years earlier, in an effort to dissuade other Luna investors from taking the same route.

“If you are considering taking your own life, I sincerely hope you reconsider your feelings,” they wrote.

“Whatever it is that you are going through, like everything else in life that once was, will pass. A brighter day will come and you will be surprised how life opens its doors to you again if you allow it.’

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How Jim Carrey’s film The Truman Show fueled a psychiatric delusion https://usmail24.com/how-jim-carrey-film-truman-helped-fuel-psychiatric-delusion-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/how-jim-carrey-film-truman-helped-fuel-psychiatric-delusion-htmlns_mchannelrssns_campaign1490ito1490/#respond Mon, 05 Jun 2023 14:41:10 +0000 https://usmail24.com/how-jim-carrey-film-truman-helped-fuel-psychiatric-delusion-htmlns_mchannelrssns_campaign1490ito1490/

It was a movie that eerily predicted the modern world of mass surveillance and social media, where millions document their daily lives on platforms like Instagram and TikTok. Released 25 years ago today, The Truman Show starred Jim Carrey as the eponymous Truman Burbank, whose entire life was a fiction designed to entertain millions of […]

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It was a movie that eerily predicted the modern world of mass surveillance and social media, where millions document their daily lives on platforms like Instagram and TikTok.

Released 25 years ago today, The Truman Show starred Jim Carrey as the eponymous Truman Burbank, whose entire life was a fiction designed to entertain millions of people around the world.

The film, directed by Peter Weir and written by Andrew Niccol, grossed more than $264 million worldwide. garnered three Academy Award nominations for Best Supporting Actor, Original Screenplay and Director.

But it also eventually gave its name to a psychological delusion in which patients — of whom there were hundreds — believe themselves, like Truman, to be the subject of a TV show.

One sufferer killed his father and sister believing they were revealing his life to the world as part of a game show, another allegedly assaulted a toddler and his mother while thinking he should “get off the Truman Show.”

Released 25 years ago today, The Truman Show told the story of a small-town insurance salesman whose every move was watched by millions around the world. Above: Jim Carrey as Truman Burbank

In the film, Truman’s every move from the moment of his birth is documented by 5,000 cameras placed all over his hometown of Seahaven Island, which is effectively a giant TV studio.

Everyone in Seahaven, including his wife Meryl – played by Laura Linney – is an actor.

As his life as an insurance salesman unfolds on screens 24 hours a day, a loyal viewership of 1.5 billion people around the world watches.

In what becomes his catchphrase, he cheerfully says to his friends and neighbors, “In case I don’t see you, good afternoon, good evening, and goodnight.”

Truman eventually begins to suspect his life is a fiction after a series of clues emerge, including the moment a lighting rig falls from the “sky.”

He decides to flee the made-up world, much to the anger of the show’s creator, Christof, who is played by Ed Harris.

In the film, Truman's every move from birth has been documented by 5,000 cameras placed all over his hometown of Seahaven Island, which is effectively a giant TV studio.  Everyone in Seahaven, including his wife Meryl - played by Laura Linney (left) - is an actor

In the film, Truman’s every move from birth has been documented by 5,000 cameras placed all over his hometown of Seahaven Island, which is effectively a giant TV studio. Everyone in Seahaven, including his wife Meryl – played by Laura Linney (left) – is an actor

While his life as an insurance salesman plays out on screens 24 hours a day, 1.5 billion viewers watch him worldwide

While his life as an insurance salesman plays out on screens 24 hours a day, 1.5 billion viewers watch him worldwide

Truman eventually begins to suspect his life is a fiction after a series of clues emerge, including the moment a lighting rig falls from the

Truman eventually begins to suspect his life is a fiction after a series of clues emerge, including the moment a lighting rig falls from the “sky.”

Jim Carrey is seen as Truman Burbank waving to neighbors in his hometown

Jim Carrey is seen as Truman Burbank waving to neighbors in his hometown

When the movie came out, reality television was still in its infancy. The hugely successful Big Brother, originally a Dutch creation, premiered in 1999.

The show saw ordinary people sharing a home for several weeks as television cameras documented their every move.

From then on, the reality genre would become a global phenomenon, with shows like The Only Way is Essex and Keeping Up with the Kardashians proving to be extremely popular.

The Truman Show also basically foresaw both the mass surveillance and widespread use of social media in the modern world.

With the former, millions of CCTV cameras keep a close eye on ordinary citizens in Britain and elsewhere.

In the latest document, millions document every detail of their lives on Instagram and TikTok, for example.

And although the film was released towards the end of the 20th century, its premise went back thousands of years to the Allegory of the Cave by the Greek philosopher Plato.

In it, Plato depicted a group of people who had spent their entire lives chained to the wall of a cave.

The shadows they see projected on the wall from objects passing in front of a fire eventually get a name.

And while they are not a reflection of reality, the shadows are real to them.

Christof evokes this feeling when he says: ‘We accept the reality of the world that is presented to us. It’s that simple.’

Truman syndrome was initially named and documented by siblings, Dr. Joel Gold and his brother Ian.

It often affects successful people, who may end up believing that they are being filmed all the time and that the world is not real to them.

In 2009, Australian man Anthony Waterlow killed his father and sister because he believed they were broadcasting his life to the world as part of a game show to kill him or convince him to kill himself.

When examined by a psychologist, he specifically mentioned The Truman Show.

Truman decides to flee the made-up world, much to the anger of the show's creator, Christof (above), who is played by Ed Harris

Truman decides to flee the made-up world, much to the anger of the show’s creator, Christof (above), who is played by Ed Harris

Laura Linney plays Truman's wife Meryl as she shows her husband a potato peeler she just bought, all the while promoting it to millions

Laura Linney plays Truman’s wife Meryl as she shows her husband a potato peeler she just bought, all the while promoting it to millions

Truman suspects his world to be fiction and eventually breaks free from the fantasy world

Truman suspects his world to be fiction and eventually breaks free from the fantasy world

Truman's best friend Louis Coltrane, played by Noah Emmerich, is also an actor

Truman’s best friend Louis Coltrane, played by Noah Emmerich, is also an actor

And in 2007, psychiatrist William Johns III allegedly assaulted a 2-year-old and his mother in New York City after he left his Florida home because he had to “get away from the Truman Show” that he believed was filming him in his residence.

The condition was named and documented by expert Dr Joel Gold and his brother Ian.

In an article in the journal Cognitive Neuropsychiatry they described it as: ‘…a new delusion, mainly persecutive in form, in which the patient believes that he is being filmed and that the films are broadcast for the amusement of others.

“We describe a series of patients who presented with a delusional system according to which they were the subject of something resembling a reality TV show…”

They investigated the lives of five patients who believed they were the focus of a secret TV show.

A patient walked into a federal building in New York City and demanded to see “the warden.”

He said he had to come to Manhattan because he believed the 2001 World Trade Center attacks were faked for the TV show filmed around him.

The man said he had to see for himself whether the Twin Towers were still standing. If they weren’t, he said, that would be the last proof that he was the reluctant star of a reality TV show.

Another was convinced that his every move was being secretly filmed for a TV match.

A third believed everything – the news, his psychiatrists, the drugs they prescribed – was part of a fake staged world in which he was the involuntary star.

In August 2008, another magazine article recounted how a 26-year-old mailman “felt like the world was a little unreal, like he was the eponymous hero” on The Truman Show.

The reviews for the film itself were mostly positive.

Christopher Tookey wrote in the Daily Mail in 1998: ‘The film works well as a surreal nightmare, in the vein of the TV series The Prisoner, or the horror classic Invasion Of The Body Snatchers.

Carrey is seen as Truman alongside his wife and 'mother', who is played by Holland Taylor

Carrey is seen as Truman alongside his wife and ‘mother’, who is played by Holland Taylor

The show airs 24 hours a day, so viewers can even tune in to watch Truman sleep

The show airs 24 hours a day, so viewers can even tune in to watch Truman sleep

“It’s convincing as a celebrity nightmare, of what the world could be like if it really revolved around you and no one acted normal in front of you.”

Famed American critic Roger Ebert, who gave the film four stars, added, “I enjoyed “The Truman Show” at its level of comedy and drama; I loved Truman the same way I loved Forrest Gump – because he was a good man, honest and easy going.

But the underlying ideas made the movie more than just entertainment.

‘Like ‘Gattaca’, the previous film written by Niccol, it portrays the new values ​​that technology imposes on humanity.

“Because we can engineer genetics, because we can broadcast real lives — of course we have to, right? But are these good things to do?

“The irony is that the people who will ultimately answer that question are the ones produced by the process.”

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