lowers – USMAIL24.COM https://usmail24.com News Portal from USA Wed, 15 Nov 2023 21:40:51 +0000 en-US hourly 1 https://wordpress.org/?v=6.4.4 https://usmail24.com/wp-content/uploads/2024/01/Untitled-design-1-100x100.png lowers – USMAIL24.COM https://usmail24.com 32 32 195427244 Harper Collins LOWERS the price of Meghan Markle’s friend Omid Scobie’s new book about the British monarchy – weeks before it hits shelves https://usmail24.com/harper-collins-slashes-price-omid-scobie-book-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/harper-collins-slashes-price-omid-scobie-book-htmlns_mchannelrssns_campaign1490ito1490/#respond Wed, 15 Nov 2023 21:40:51 +0000 https://usmail24.com/harper-collins-slashes-price-omid-scobie-book-htmlns_mchannelrssns_campaign1490ito1490/

Harper Collins has already slashed the price of Meghan Markle’s friend Omid Scobie’s new book about the British monarchy – weeks before it goes on sale. Endgame, which aims to give readers a glimpse into ‘the royal family and the monarchy’s struggle for survival’, has already been reduced in price on the official website. The […]

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Harper Collins has already slashed the price of Meghan Markle’s friend Omid Scobie’s new book about the British monarchy – weeks before it goes on sale.

Endgame, which aims to give readers a glimpse into ‘the royal family and the monarchy’s struggle for survival’, has already been reduced in price on the official website.

The book was originally going to cost $32, but is now $25.60.

This is despite the fact that it is only on pre-order and won’t hit the shelves until November 28.

Dey Street Books, an imprint of Harper Collins, has been contacted for comment.

Harper Collins has already slashed the price of Meghan Markle’s friend Omid Scobie’s new book about the British monarchy – weeks before it goes on sale

Endgame, which aims to give readers a glimpse into 'the royal family and the monarchy's struggle for survival', has already been reduced in size on the official website

Endgame, which aims to give readers a glimpse into ‘the royal family and the monarchy’s struggle for survival’, has already been reduced in size on the official website

Endgame is described as an “explosive book and a penetrating examination of the current state of the British monarchy – an unpopular king, a power-hungry heir to the throne, a queen willing to go to any lengths to maintain her image, and a Prince. forced to start a new life after being betrayed by his own family.’

Omid Scobie, the author, also wrote Finding Freedom – about the departure of his girlfriend Meghan Markle and her husband Prince Harry from the royal family.

The description of the $25.60 book explains: “The death of Queen Elizabeth II has torn the already broken foundations of the House of Windsor and dismantled the protective shield around it.

‘With an institution long plagued by outdated ideas around race, class and money, the monarchy and those who support it are now exposed and at odds with a rapidly modernizing world.

Omid Scobie, the author, also wrote Finding Freedom – about the departure of his girlfriend Meghan Markle and her husband Prince Harry from the royal family

Omid Scobie, the author, also wrote Finding Freedom – about the departure of his girlfriend Meghan Markle and her husband Prince Harry from the royal family

Omid Scobie’s claims from his new book, Endgame

  • William ignored Harry when he asked how he planned to get to Scotland;
  • He ended up booking a £30,000 charter flight from Luton to Aberdeenshire;
  • Charles said he had to come without Meghan. Bron claims she ‘wasn’t wanted’;
  • Harry had ‘no idea’ of what was going on at Balmoral when his plane took off;
  • But ‘sources’ told the newspapers that Charles had personally informed his son;
  • William believes Harry has been ‘brainwashed by an army of therapists’.

‘Relying on his vast experience as a royal reporter and more than a decade of conversations and interviews with current and former palace staff, trusted friends of the royal family and even the family members themselves, Scobie pulls back the curtain on an institution in turmoil. to show what the monarchy must change in order to survive.’

One chapter of the book will be called ‘Race and the Royals: Institutional Bigotry and Denial’ and is likely to address claims of racism within the institution.

It comes as the royal family faces new claims from Harry and Meghan’s biographer Scobie, just hours after the Duke of Sussex reportedly had a “warm” phone call with King Charles to mark his 75th birthday.

The Duke of Sussex is believed to have called his father on his special day yesterday to wish him a happy birthday – a phone call believed to be the estranged royal’s first in six months.

Meghan Markle is also said to have spoken to her father-in-law to pass on her wishes from California. And the couple’s children, Archie and Lilibet, recorded a video singing “Happy Birthday” to their grandfather, the Telegraph newspaper reported.

The report claimed that Charles and Harry will speak again next week after their phone call marked a ‘shift’ in tone and a ‘turning point’ between the pair.

But now Mr Scobie has shared an extract from his new book, Endgame, leaking explosive claims including that Prince Harry was ‘kept in the dark’ about the Queen’s health in the hours before she died.

Harry and Meghan imagined themselves attending the closing ceremony of the Invictus Games

Harry and Meghan imagined themselves attending the closing ceremony of the Invictus Games

The Sussex family together: Harry, Meghan, Archie and Lilibet

The Sussex family together: Harry, Meghan, Archie and Lilibet

Mr Scobie, who previously released a biography of the Sussexes titled ‘Finding Freedom’, said Harry, 39, and his 42-year-old wife Meghan had ‘no idea’ the royal family was preparing for the death of the couple. queen last year.

The author also suggests that William and Harry’s relationship is beyond repair, as the Prince of Wales sees his brother as a ‘turncoat’.

And in the extract shared with People, he claims there is ‘no turning back’ for the brothers and ‘absolutely nothing has changed’ since the Duke of Sussex released Spare earlier this year.

It is not known how the new book could influence the rapprochement. Buckingham Palace has declined to comment on the extract.

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Daily statins could be replaced by gene therapy that lowers cholesterol within a few years with a single dose, scientists claim https://usmail24.com/daily-statins-replaced-gene-therapy-cuts-cholesterol-single-dose-years-scientists-claim-htmlns_mchannelrssns_campaign1490ito1490/ https://usmail24.com/daily-statins-replaced-gene-therapy-cuts-cholesterol-single-dose-years-scientists-claim-htmlns_mchannelrssns_campaign1490ito1490/#respond Sun, 12 Nov 2023 21:33:08 +0000 https://usmail24.com/daily-statins-replaced-gene-therapy-cuts-cholesterol-single-dose-years-scientists-claim-htmlns_mchannelrssns_campaign1490ito1490/

The use of statins could be replaced ‘within ten years’ by the gene-manipulating drug Verve-101 Drug alters DNA in cholesterol-regulating cells to stop production Nine have been successfully treated by Verve-101 to date and studies will continue to expand By Barney Calman Published: 3:50 PM EST, November 12, 2023 | Updated: 3:54 PM EST, November […]

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  • The use of statins could be replaced ‘within ten years’ by the gene-manipulating drug Verve-101
  • Drug alters DNA in cholesterol-regulating cells to stop production
  • Nine have been successfully treated by Verve-101 to date and studies will continue to expand

Daily statins taken by millions of people to ward off heart attacks and strokes could be replaced by a gene-editing injection ‘within a decade’, scientists claim.

The remarkable new drug manipulates the DNA in cholesterol-regulating cells to stop production of the substance after a single dose.

It was unveiled yesterday at the American Heart Association’s annual Scientific Sessions in Philadelphia.

Trial results showed that the single injection reduced ‘bad’ LDL cholesterol by more than 50 percent.

Los Angeles-based cardiologist Professor Karol Watson predicted ‘a brave new world’ in heart treatment: ‘This study showed that [gene] With editing you can sustainably lower LDL.’

Daily use of statins could be a thing of the past thanks to a revolutionary new gene editing drug

Experts behind the treatment, called Verve-101, believe the effect is long-lasting and possibly permanent.

They admit that the research is still in its early stages and say their findings open up the possibility that high cholesterol can be effectively ‘cured’ or prevented from becoming a problem in the first place.

“This is a potential game changer in the treatment of heart disease,” says Dr. Sekar Kathiresan, one of the cardiologists behind Verve-101.

He added: ‘We have shown that a one-off therapy could be the future.’

So far, nine patients with a genetic condition called familial hypercholesterolemia – which causes sky-high LDL levels that trigger heart attacks – have been successfully treated.

The studies will soon be expanded to broader groups, including people with existing heart disease. “We hope the treatment will be available by the end of the decade,” Dr Kathiresan added.

The drug is based on CRISPR technology, which can delete and rewrite parts of the DNA in cells.

Unlike other CRISPR-based treatments, which can cost more than £1 million per dose, Verve-101 is possible to mass-produce, Dr Kathiresan added.

Nine patients have been successfully treated so far, and the studies will soon be expanded to larger groups

Nine patients have been successfully treated so far, and the studies will soon be expanded to larger groups

He said: ‘We expect it will cost no more than other one-off heart procedures such as stent or heart bypass surgery.’

Statins are one of the most prescribed medicines in Britain, with around eight million adults taking them, and more than 71 million prescriptions for statins are given each year.

The drugs can be remarkably effective, reducing the risk of heart attack by up to 50 percent and the risk of stroke by a third – at a cost of just £15 per patient per year.

Professor Watson said the biggest concern about the new treatment was safety: ‘If you’re editing the human genome that’s a big problem, so we need to make sure it’s very safe.’

Dr. Andrew Bellinger, chief scientific and medical officer at Verve Therapeutics, said large-scale trials involving thousands of heart disease patients are planned to start in 2025.

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