Health

Wonder drug for Alzheimer’s, Lecanemab, which can slow the disease, is set to be approved for use in the UK in ‘biggest breakthrough’ in decades

A wonder drug that could slow Alzheimer’s disease is soon to be approved for use in Britain.

Lecanemab is the first treatment shown to slow the condition, slowing cognitive decline by 27 percent.

Experts are calling it ‘the beginning of the end’ for the disease, which affects around 900,000 Britons.

The Medicines and Healthcare products Regulatory Agency (MHRA) is set to approve the drug for private prescription in the UK.

The National Institute of Health and Care Excellence will then decide whether the treatment will be offered through the NHS.

Alzheimer's disease affects 900,000 Britons (Stock photo)

Alzheimer’s disease affects 900,000 Britons (Stock photo)

Lecanemab, sold under the brand name Leqembi, is a monoclonal antibody drug used to treat Alzheimer's disease

Lecanemab, sold under the brand name Leqembi, is a monoclonal antibody drug used to treat Alzheimer’s disease

Alzheimer's disease is the most common cause of dementia. The disease can cause anxiety, confusion and loss of short-term memory.

Alzheimer’s disease is the most common cause of dementia. The disease can cause anxiety, confusion and loss of short-term memory.

The drug, which is administered through an IV every two weeks, was approved in the US last year.

However, last month the European Medicines Agency refused to grant a licence to the drug over concerns about side effects including ‘swelling’ and ‘possible bleeding in the brain’.

Professor John Hardy of the UCL Institute of Neurology described the drug as ‘the biggest breakthrough in the fight against Alzheimer’s in decades’.

He has previously hailed the “groundbreaking” treatment as the “beginning of the end” for Alzheimer’s.

However, Dr Max Pemberton noted in his Daily Mail column last week that lecanemab – and also donanemab, another Alzheimer’s drug – ‘is likely to provide only a small improvement in symptoms’.

A study published in the New England Journal of Medicine found that the drug slightly improved cognition, but could have significant side effects (Stock Image)

A scientist picks up a sample to be used for research into Alzheimer's disease

A scientist picks up a sample to be used for research into Alzheimer’s disease

A study published last year in the New England Journal of Medicine found that the drug modestly improved cognition, but could have significant side effects.

An MHRA spokesperson told The Daily Telegraph: ‘We are currently completing a thorough review of the evidence supporting lecanemab in the treatment of Alzheimer’s disease.’

They added that more information will be provided in due course.

What is Alzheimer’s?

Alzheimer’s disease is a progressive, degenerative disease of the brain in which the build-up of abnormal proteins causes nerve cells to die.

This disrupts the transmitters that transmit the messages and causes the brain to shrink.

In the US, more than 5 million people suffer from the disease. It is the sixth leading cause of death there. More than 1 million Britons have the disease.

WHAT’S HAPPENING?

When brain cells die, the functions they perform are lost.

These include memory, orientation and the ability to think and reason.

The disease develops slowly and gradually.

On average, patients live five to seven years after diagnosis, but some live for 10 to 15 years.

EARLY SYMPTOMS:

  • Loss of short-term memory
  • Disorientation
  • Behavioral changes
  • Mood swings
  • Problems with money matters or making a phone call

LATER SYMPTOMS:

  • Severe memory loss, forgetting close relatives, familiar objects or places
  • Becoming anxious and frustrated by the inability to understand the world, leading to aggressive behavior
  • Eventually losing the ability to walk
  • May have problems with eating
  • The majority will eventually require 24-hour care

Source: Alzheimer Association

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