Breakthrough of cancer as doctors reveal the way to zap tumors in oblivion without chemo

A new cancer treatment that uses light can remove the need for hard chemotherapy or radiotherapy.

Texas Researchers have devised a way to use infrared light as a Jackhammer who can tear cancer Cells apart from the inside, which show in studies to have eliminated melanomas, the deadliest form of skin cancer.

A synthetic blue dye that is often used in hospital image formation naturally binds to cancer cells.

Researchers discovered that when the cancer cells were sagged with infrared light, the violent shaking caused that tore through the membrane of the cancer cell, causing it to died without heat or hard drugs.

The last breakthrough method -known as vibronic-driven effects a 99 percent efficiency against laboratory cultures of human skin cancer cells, and half of the mice with melanoma tumors became cancer-free after just one treatment.

“It is a whole new generation of molecular machines that we call molecular Jackhammers,” said Rice University Nanotechnologist Dr James Tour.

Near-infrared light Can penetrate up to 10 cm in the body and reach organs and bones without surgery. Light particles can also be functionalized to bind to cancer cells alone, causing damage to healthy cells.

The treatment itself is very focused because the atoms of dye bind to the receptors on cancer cells, while healthy cells remain largely untouched. It has already demonstrated in Follow -Up studies to kill colorectal cancer, prostate cancer and breast cancer cells.

The next step will determine whether this same molecular Jackhammer will destroy cancer cells in people.

“This study is about a different way to treat cancer with the help of mechanical forces on a molecular scale,” said Ciceron Ayala-Orozco, a rice research scientist who is a main author in the study.

If it is scaled up to human patients, the impact of the treatment can wipe. An estimated 1.5 million Americans live with melanoma, 1.4 million have colorectal cancer and 300,000 men have prostate cancer.

In 2025, approximately 316,950 women will be diagnosed with severe, invasive breast cancer.

The modest dye in rural hospitals is an important feature of vibronic-driven action.

After binding to receptors on melanoma cells, it is attacked with infrared light, which causes an earthquake in the cell. The dye atoms begin to vibrate together.

The electrons of the dye synchronize up in a “plasmon” – a wave of collective movement. These energy reasons with the natural vibrations of the molecule, so that the entire structure shudders 41 trillion times per second.

The violent oscillating energy is transferred directly into the fat membrane of the cell, while holes on nano scale crack open, allowing liquid and foreign molecules to flood in.

Ciceron Ayala-Orozco, a rice research scientist who is a main author in the study, said: “This study is about another way to treat cancer using mechanical forces on molecular scale”

This fast-moving mechanical power is such that “everything around it is dismantled,” said Ayala-Orozco.

The cancer cell crumbles as the holes in its membrane increase and dies without further use of a medicine or radiation treatment.

The findings of the Texas team were published in the magazine Natural chemistry.

Ayala orozco said: ‘These molecules are simple dyes that people have been using for a long time.

‘They are biocompatibel, stable in water and very good at attaching to the fat outdoor separation of cells. But although they were used for imaging, people did not know how to activate it as plasmons. ‘

After years of struggling to make it work with blue-light activated engines against mood tumors, Ayala-Orozco turned to explore completely different approaches.

“I started to think that I might not need an engine, but a molecule that slightly absorbs slightly, in the hope that this molecule could be activated and could not move in another way due to rotation,” he said Healio.

‘Then I started thinking about some molecules called Cyanines and I started to connect the dots to a characteristic of photophysics called Plasmons, which I studied during my doctorate to treat cancer. They are activated by near-infrared light. At one point I decided that I should try this. ‘

The next step will determine whether this same molecular Jackhammer will destroy cancer cells in people

The graph above shows the estimated diagnoses of cancer before 2025 by the type of cancer. Breast, prostate and lung cancer is expected to be the most common cancers this year

When researchers played their microscopes on other cancer types, they made an exciting discovery: the molecular Jackhammers turned out to be just as devastating against prostate, breast and colorectal cancer cells in petri dishes.

“Regardless of which line, we are able to eliminate 100 percent on the cell culture,” said Ayala-Orozco.

The university will have to collaborate with a private company to scale up, overcome regulatory obstacles and introduce human tests, “hopefully, within 5 to 7 years,” said Ayala-Orozco.