Amy Schumer appears for the first time since responding to speculation about 'puffy' faces while having coffee with husband Chris Fischer in New York

Amy Schumer was spotted having coffee with her husband Chris Fischer in New York on Friday, just one day after breaking her silence over concerns about her “puffy and swollen” face.

The comedian, 42 – who opened up about her health struggles with endometriosis and autoimmune diseases – was seen getting some fresh air alongside the chef, 44, who she tied the knot with in 2018.

The star dressed in a thick, red jacket that zipped up the front and also opted for dark blue trousers.

She also donned a pair of black and white colored sneakers to stay comfortable during the outing.

A black hat was placed on her head to complete her overall look for the day excursion.

The mother of one held a hot drink in her hand as her husband walked beside her, who also opted for comfort.

Chris put on a pair of gray sweatpants and a green and black colored checked jacket that buttoned up the front.

He put a gray beanie on his head to help him stay warm in the cooler temperatures, and wore a pair of sneakers tied with laces.

The two enjoyed a quick errand in the Big Apple and also had a chat as they headed to their next destination.

Amy's latest outing comes just one day after she broke her silence to criticize her “puffy and swollen” face by taking to Instagram on Thursday.

While celebrating the second season of her Hulu series, Life & Beth, she also got candid about her recent appearance and revealed to her fans and followers that she struggles with endometriosis and autoimmune diseases.

She recently appeared as a guest on The Tonight Show With Jimmy Fallon on Wednesday, but a clip quickly went viral on social media, with doctors asking the audience the question: “What happened to Amy's face?”

Schumer wrote, “Thank you so much for everyone's input on my face! I have enjoyed feedback and consultation about my appearance, as all women have for almost 20 years. And you're right: it's thicker than normal right now.'

'I have endometriosis, an autoimmune disease that every woman should read about. There are some medical and hormonal things going on in my world right now, but I'm doing well,” the Trainwreck star continued.

'Historically, women's bodies have hardly been medically examined compared to men. The book “All in her head” explains this well. I also believe that a woman needs no excuse for her physical appearance and is not owed an explanation.”

'But I wanted to take the opportunity to advocate for self-love and acceptance of the skin you're in. Just like any other woman/person, some days I feel confident and good and other days I want to put a bag over my head. '

'But I feel strong and beautiful and so proud of this TV show that I created. Wrote. Starring and directed. Maybe we can concentrate on that for a while.'

The actress concluded, “I had backup dancers on Fallon, but my face is still the headline, hahaha. I hope you enjoy life and Beth. Love and solidarity. Amy.'

The star also joked about her appearance during an appearance on Good Morning America this week – when she picked up a candy heart that said “inflated.”

Doctors and viewers quickly assumed that Amy is taking steroids like prednisone and dexamethasone, which are used to treat inflammation.

Medical professionals also suggested that Amy could have an autoimmune disease, such as lupus or a hormonal imbalance, which can also cause swelling.

The actress has previously been open about her struggles with endometriosis, chronic pain and Lyme disease, all of which can lead to steroid use and facial swelling.

In September 2021, Amy underwent surgery for endometriosis and had both her appendix and uterus removed.

The actor has admitted to using cheek fillers in the past – a treatment known to cause bags under his eyes if done poorly.

Dr. Jebra Faushay, a gender studies academic, wrote on X, formerly Twitter: “I need all the surgeons and doctors to voice their opinions here. Serious question: What happened to Amy's face? Is it normally this size?'

Sarah Absher, a registered nurse, responded, “Honestly, it looks like what's called 'moon face,' a condition associated with long-term steroid use.”

Users pointed to the specific steroids prednisone and dexamethasone, which are used for conditions that cause inflammation, such as asthma, allergic reactions, inflammatory bowel disease and migraines.

These are different from anabolic steroids, which increase testosterone levels to improve athletic performance.

'Moon face' is a common side effect, causing the face to become round, full and swollen.

Medications like prednisone are meant to be taken for only a few days at a time because long-term use can cause adrenal insufficiency, also known as Addison's disease. This ensures that the body does not produce enough of the stress hormone cortisol.

Lisa Clark, a nurse in Miami, also noted that Amy's swelling could be due to a cortisol imbalance.

Even without the use of steroids, a cortisol imbalance can occur due to stress or tumors pressing on the adrenal glands or pituitary gland of the brain.

“I've also seen similar effects with lupus,” Ms. Clark said, nothing that would be difficult to know for sure without more details about Amy's medical history.

Lupus is an autoimmune disease that occurs when the immune system attacks the body's own tissues and organs.

According to the Mayo Clinic, side effects include fatigue, fever, joint pain, swelling, a butterfly-shaped rash on the face, skin lesions, shortness of breath, chest pain and dry eyes. Prednisone is also often prescribed for lupus symptoms.

In addition to the social media speculation, Amy has been open about her struggles with several other conditions.

In 2022, she opened up about her battle with endometriosis, which occurs when tissue around the uterus grows and becomes trapped, causing debilitating pain and heavy bleeding, especially during menstrual cycles.

In a CBS News interview, Amy called it a “lonely, lonely disease.” Many patients with endometriosis take medications to regulate their reproductive hormones, known as progestins.

In 2020, the actress also revealed that she had been diagnosed with Lyme disease, which is transmitted by black-legged ticks that carry the bacteria Borrelia burgdorferi or, more rarely, Borrelia mayonii.

Common symptoms of Lyme disease include a bullseye-shaped rash, fever, headache, extreme fatigue, joint stiffness and muscle pain, according to the Mayo Clinic.

Additionally, the condition can cause swollen lymph nodes, which can make the cheeks look swollen.

And in 2021, Amy opened up about her experience with facial fillers, cosmetic injections that smooth lines and wrinkles.